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2014 ; 30
(9
): 920-6
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Phylogenetic and temporal dynamics of human immunodeficiency virus type 1B in
China: four types of B strains circulate in China
#MMPMID25050980
Ye J
; Lu H
; Su X
; Xin R
; Bai L
; Xu K
; Yu S
; Feng X
; Yan H
; He X
; Zeng Y
AIDS Res Hum Retroviruses
2014[Sep]; 30
(9
): 920-6
PMID25050980
show ga
To investigate the origin and evolutionary history of the spread of HIV-1 subtype
B in China, a total of 409 sequences of pol gene sampled from 1994 to 2012 in 29
provinces across China was subjected to phylogenetic and Bayesian molecular clock
analyses. The study reveals that subtype B strains in China are genetically
diverse and can be classified into four distinct subgroups, namely B' (Thai-B),
BJ-B (Beijing-B), Pan-B (Pandemic-B), and TW-B (Taiwan-B), according to the
origin of the sequences. The BJ-B and TW-B are reported for the first time.
Phylogeographic analysis reveals that B' exhibits a nationwide, transprovincial
distribution, and is found in 21 provinces in China in this study, whereas the
Pan-B, BJ-B, and TW-B lineages are restricted to particular regions. From the
same common ancestor of B', there arise two subclusters in which sequences from
Yunnan occupy the basal position. The times of the most recent common ancestors
(tMRCAs) of B' and BJ-B are estimated to be 1983.6 (1975.9-1990.3) and 1995.3
(1989.6-2000.3), respectively. The skyline plot profile reveals an exponential
decrease in median number of effective infections of subtype B in China from 1994
to 2009. The existence of four types of B clades also indicates distinct
transmission networks of subtype B, originating from different introduction
events at different time points. The data presented here offer a new perspective
on the epidemic of HIV-1 subtype B in China.