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1975 ; 11
(3
): 424-8
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gab.com Text
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English Wikipedia
Virus susceptibility of mouse hemopoietic cells in vitro: inhibition of
granulocyte-macrophage precursor cells by Newcastle disease virus
#MMPMID163791
McNeill TA
; Havredaki M
; Gould EA
; Cosby L
Infect Immun
1975[Mar]; 11
(3
): 424-8
PMID163791
show ga
Normal mouse bone marrow cells were exposed to encephalomyocarditis virus (EMC),
reovirus type 3 (REO3), influenza virus (FLU), and Newcastle disease virus (NDV)
then assayed for granulocyte-macrophage precursor cells by the technique of
colony formation in agar. Exposure to EMC, REO3, and FLU caused a slight but
variable loss of colony-forming potential, whereas exposure to NDV caused a very
marked loss. NDV acted directly on the cells, not indirectly through release of
colony-inhibiting factors or destruction of colony-stimulating factor.
Experiments with NDV inactivated by heat, ether, or ultraviolet irradiation
indicated that colony inhibition was associated with fully infective virus, even
though some of the inactivated preparations had retained full hemagglutinin,
neuraminidase, or hemolytic activity.