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10.1098/rspb.2014.0919 http://scihub22266oqcxt.onion/10.1098/rspb.2014.0919 C4150316!4150316 !25143031     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25143031 &cmd=llinks): Failed to open stream: HTTP request failed! 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Nasal aerodynamics protects brain and lung from inhaled dust in subterranean diggers, Ellobius talpinus |pdf=|usr=}}{{25143031 }} gab.com Text Nasal aerodynamics protects brain and lung from inhaled dust in subterranean diggers, Ellobius talpinus JO: Proc Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25143031 #FOAvip Inhalation of air-dispersed sub-micrometre and nano-sized particles presents a risk factor for animal and human health. Here, we show that nasal aerodynamics plays a pivotal role in the protection of the subterranean mole vole Ellobius talpinus from an increased exposure to nano-aerosols. Quantitative simulation of particle flow has shown that their deposition on the total surface of the nasal cavity is higher in the mole vole than in a terrestrial rodent Mus musculus (mouse), but lower on the olfactory epithelium. In agreement with simulation results, we found a reduced accumulation of manganese in olfactory bulbs of mole voles in comparison with mice after the inhalation of nano-sized MnCl2 aerosols. We ruled out the possibility that this reduction is owing to a lower transportation from epithelium to brain in the mole vole as intranasal instillations of MnCl2 solution and hydrated nanoparticles of manganese oxide MnO · (H2O)x revealed similar uptake rates for both species. Together, we conclude that nasal geometry contributes to the protection of brain and lung from accumulation of air-dispersed particles in mole voles. Twit Text FOAVip Nasal aerodynamics protects brain and lung from inhaled dust in subterranean diggers, Ellobius talpinus ????Proc Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25143031 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25143031 #FOAvip English Wikipedia <ref>{{Cite pmid|25143031 }}</ref> Nasal aerodynamics protects brain and lung from inhaled dust in subterranean diggers, Ellobius talpinus #MMPMID25143031 Moshkin MP ; Petrovski DV ; Akulov AE ; Romashchenko AV ; Gerlinskaya LA ; Ganimedov VL ; Muchnaya MI ; Sadovsky AS ; Koptyug IV ; Savelov AA ; Troitsky SY ; Moshkn YM ; Bukhtiyarov VI ; Kolchanov NA ; Sagdeev RZ ; Fomin VM Proc Biol Sci 2014[Oct]; 281 (1792 ): ä PMID25143031 show ga Inhalation of air-dispersed sub-micrometre and nano-sized particles presents a risk factor for animal and human health. Here, we show that nasal aerodynamics plays a pivotal role in the protection of the subterranean mole vole Ellobius talpinus from an increased exposure to nano-aerosols. Quantitative simulation of particle flow has shown that their deposition on the total surface of the nasal cavity is higher in the mole vole than in a terrestrial rodent Mus musculus (mouse), but lower on the olfactory epithelium. In agreement with simulation results, we found a reduced accumulation of manganese in olfactory bulbs of mole voles in comparison with mice after the inhalation of nano-sized MnCl2 aerosols. We ruled out the possibility that this reduction is owing to a lower transportation from epithelium to brain in the mole vole as intranasal instillations of MnCl2 solution and hydrated nanoparticles of manganese oxide MnO · (H2O)x revealed similar uptake rates for both species. Together, we conclude that nasal geometry contributes to the protection of brain and lung from accumulation of air-dispersed particles in mole voles. |*Dust [MESH] |Aerosols [MESH] |Animals [MESH] |Arvicolinae/*anatomy & histology [MESH] |Brain [MESH] |Inhalation Exposure [MESH] |Lung [MESH] |Mice/anatomy & histology [MESH] |Models, Anatomic [MESH] |Nanoparticles [MESH] |Nasal Cavity/*anatomy & histology/physiology [MESH]Nasal aerodynamics protects brain and lung from inhaled dust in subter(epmc).pdf DeepDyve Pubget Overpricing