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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Trends+Cell+Biol 2014 ; 24 (9): 546-53 Nephropedia Template TP
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Alteration of miRNA activity via context-specific modifications of Argonaute proteins #MMPMID24865524
Jee D; Lai EC
Trends Cell Biol 2014[Sep]; 24 (9): 546-53 PMID24865524show ga
microRNAs (miRNAs) are enclosed within Argonaute proteins, the downstream effectors of small RNA-mediated gene silencing. As miRNAs mediate extensive networks of post-transcriptional control, cells have evolved multiple strategies to control their activity with precision. A growing theme of recent years regards how post-translational modifications of Argonaute proteins, such as prolyl-hydroxylation, phosphorylation, ubiquitination, and poly-ADP-ribosylation, alter miRNA activity at global or specific levels. In this review, we discuss recent advances on Argonaute modifications in mammalian cells, and emphasize how such alterations modulate small RNA function to coordinate appropriate downstream cellular responses. These findings provide a framework to understand how Argonaute protein modifications are linked to reorganization of post-transcriptional regulatory networks, enabling dynamic responses to diverse external stimuli and changing environmental conditions.