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10.1111/jsm.12620 http://scihub22266oqcxt.onion/10.1111/jsm.12620 C4149830!4149830!24953642     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Sex+Med 2014 ; 11 (9): 2153-63 Nephropedia Template TP {{tp|p=24953642|t=2014. Angiotensin-(1-7) Reverses Angiogenic Dysfunction In Corpus Cavernosum By Acting On The Microvasculature And Bone Marrow-Derived Cells In Diabetes |pdf=|usr=}}{{24953642}} gab.com Text Angiotensin-(1-7) Reverses Angiogenic Dysfunction In Corpus Cavernosum By Acting On The Microvasculature And Bone Marrow-Derived Cells In Diabetes JO: J Sex Med http://www.kidney.de/pget.php?&tw=1&pmid=24953642 #FOAvip Introduction: Angiotensin (Ang)-(1-7) is a recently identified vasoprotective heptapeptide and it appears to activate the reparative functions of bone marrow-derived stem/progenitor cells (BMPCs). Aim: This study evaluated the effect of Ang-(1-7) in the angiogenic function of cavernosum in type 1 diabetes (T1D) and delineated the role of BMPCs in this protective function. Methods: T1D was induced by streptozotocin in mice and mice with 20-24 weeks of diabetes were used for the study. Ang-(1-7) was administered subcutaneously by using osmotic pumps. Cavernosa, and BMPCs from peripheral blood and bone marrow were evaluated in different assay systems. Main outcome measures: Angiogenic function was determined by endothelial tube formation in matrigel assay. Circulating BMPCs were enumerated by flow cytometry and proliferation was determined by BrdU incorporation. Cell-free supernatant of BMPCs were collected and tested for paracrine angiogenic effect. Expression of angiogenic factors in BMPCs and cavernosa were determined by real-time PCR. Results: Ang-(1-7) (100 nM) stimulated angiogenesis in mouse cavernosum that was partially inhibited by Mas1 receptor antagonist, A779 (10 ?M) (P<0.05). In cavernosa of T1D, the angiogenic responses to Ang-(1-7) (P<0.005) and VEGF (100 nM) (P<0.03) were diminished. Ang-(1-7) treatment for four weeks reversed T1D-induced decrease in the VEGF-mediated angiogenesis. Ang-(1-7) treatment increased the circulating number of BMPCs and proliferation that were decreased in T1D (P<0.02). Paracrine angiogenic function of BMPCs was reduced in diabetic BMPCs, which was reversed by Ang-(1-7). In diabetic BMPCs, SDF and angiopoietin-1 were up-regulated by Ang-(1-7) and in cavernosum, VEGFR1, Tie-2 and SDF were up-regulated and angiopoietin-2 was down-regulated. Conclusions: Ang-(1-7) stimulates angiogenic function of cavernosum in diabetes via its stimulating effects on both cavernosal microvasculature and BMPCs. Twit Text FOAVip Angiotensin-(1-7) Reverses Angiogenic Dysfunction In Corpus Cavernosum By Acting On The Microvasculature And Bone Marrow-Derived Cells In Diabetes ????J Sex Med http://www.kidney.de/pget.php?&tw=1&pmid=24953642 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24953642 #FOAvip English Wikipedia <ref>{{Cite pmid|24953642}}</ref> Angiotensin-(1-7) Reverses Angiogenic Dysfunction In Corpus Cavernosum By Acting On The Microvasculature And Bone Marrow-Derived Cells In Diabetes #MMPMID24953642 Singh N; Vasam G; Pawar R; Jarajapu YP J Sex Med 2014[Sep]; 11 (9): 2153-63 PMID24953642show ga Introduction: Angiotensin (Ang)-(1-7) is a recently identified vasoprotective heptapeptide and it appears to activate the reparative functions of bone marrow-derived stem/progenitor cells (BMPCs). Aim: This study evaluated the effect of Ang-(1-7) in the angiogenic function of cavernosum in type 1 diabetes (T1D) and delineated the role of BMPCs in this protective function. Methods: T1D was induced by streptozotocin in mice and mice with 20-24 weeks of diabetes were used for the study. Ang-(1-7) was administered subcutaneously by using osmotic pumps. Cavernosa, and BMPCs from peripheral blood and bone marrow were evaluated in different assay systems. Main outcome measures: Angiogenic function was determined by endothelial tube formation in matrigel assay. Circulating BMPCs were enumerated by flow cytometry and proliferation was determined by BrdU incorporation. Cell-free supernatant of BMPCs were collected and tested for paracrine angiogenic effect. Expression of angiogenic factors in BMPCs and cavernosa were determined by real-time PCR. Results: Ang-(1-7) (100 nM) stimulated angiogenesis in mouse cavernosum that was partially inhibited by Mas1 receptor antagonist, A779 (10 ?M) (P<0.05). In cavernosa of T1D, the angiogenic responses to Ang-(1-7) (P<0.005) and VEGF (100 nM) (P<0.03) were diminished. Ang-(1-7) treatment for four weeks reversed T1D-induced decrease in the VEGF-mediated angiogenesis. Ang-(1-7) treatment increased the circulating number of BMPCs and proliferation that were decreased in T1D (P<0.02). Paracrine angiogenic function of BMPCs was reduced in diabetic BMPCs, which was reversed by Ang-(1-7). In diabetic BMPCs, SDF and angiopoietin-1 were up-regulated by Ang-(1-7) and in cavernosum, VEGFR1, Tie-2 and SDF were up-regulated and angiopoietin-2 was down-regulated. Conclusions: Ang-(1-7) stimulates angiogenic function of cavernosum in diabetes via its stimulating effects on both cavernosal microvasculature and BMPCs. äAngiotensin-(1-7) Reverses Angiogenic Dysfunction In Corpus Cavernosum(epmc).pdf DeepDyve Pubget Overpricing