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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Br+J+Radiol
2014 ; 87
(1042
): 20140276
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Meta-analysis of CT-guided transthoracic needle biopsy for the evaluation of the
ground-glass opacity pulmonary lesions
#MMPMID25051977
Yang JS
; Liu YM
; Mao YM
; Yuan JH
; Yu WQ
; Cheng RD
; Hu TY
; Cheng JM
; Wang HY
Br J Radiol
2014[Oct]; 87
(1042
): 20140276
PMID25051977
show ga
OBJECTIVE: This meta-analysis is to determine the overall diagnostic yield of
CT-guided transthoracic needle biopsy (TNB) of ground-glass opacity (GGO)
lesions. METHODS: A PubMed search was performed using "ground-glass opacity"
crossed with "core biopsy" and "needle biopsy". Test performance characteristics
with the use of forest plots, summary receiver operating characteristic curves
and bivariate random effects models were summarized. Adverse events, if reported,
were recorded. RESULTS: Our search identified 52 citations, of which 6 diagnostic
studies evaluated 341 patients. Pooled specificity estimates were 0.94 [95%
confidence interval (CI), 0.84-0.98] and sensitivity estimates were 0.92 (95% CI,
0.88-0.95), respectively. The positive likelihood ratio was 11.27 (95% CI,
4.2-30.6), the negative likelihood ratio was 0.1 (95% CI, 0.06-0.19), the
diagnostic odds ratio was 131.38 (95% CI, 39.6-436.0) and the area under the
curve was 0.97. CONCLUSION: Our data suggest that the CT-guided TNB is likely to
be a useful tool for tissue diagnosis and may serve as an alternative for further
patient management with GGO lesions. However, considering the limited studies and
patients included, large scale studies are needed to verify these findings.
ADVANCES IN KNOWLEDGE: Some studies about CT-guided TNB of GGO lesions have been
published, most have been small, single-institution case series. To our
knowledge, our study is the first systematic analysis about CT-guided TNB of GGO
lesions.