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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Biochim+Biophys+Acta 2014 ; 1839 (10): 919-30 Nephropedia Template TP
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The purine riboswitch as a model system for exploring RNA biology and chemistry #MMPMID24590258
Porter EB; Marcano-Velázquez JG; Batey RT
Biochim Biophys Acta 2014[Oct]; 1839 (10): 919-30 PMID24590258show ga
Over the past decade the purine riboswitch, and in particular its nucleobase-binding aptamer domain, has emerged as an important model system for exploring various aspects of RNA structure and function. Its relatively small size, structural simplicity and readily observable activity enable application of a wide variety of experimental approaches towards the study of this RNA. These analyses have yielded important insights into small molecule recognition, co-transcriptional folding and secondary structural switching, and conformational dynamics that serve as a paradigm for other RNAs. In this article, the current state of understanding of the purine riboswitch family is examined and how this growing knowledge base is starting to be exploited in the creation of novel RNA devices.