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10.1002/art.38723 http://scihub22266oqcxt.onion/10.1002/art.38723 C4146704!4146704!24891319     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arthritis+Rheumatol 2014 ; 66 (9): 2482-93 Nephropedia Template TP {{tp|p=24891319|t=2014. Macrophage migration inhibitory factor down-regulates the RANKL-RANK signaling pathway by activating Lyn tyrosine kinase |pdf=|usr=}}{{24891319}} gab.com Text Macrophage migration inhibitory factor down-regulates the RANKL-RANK signaling pathway by activating Lyn tyrosine kinase JO: Arthritis Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=24891319 #FOAvip Objective: Macrophage migration inhibitory factor (MIF) is an important modulator of innate and adaptive immunity as well as local inflammatory response. We previously reported that MIF down-regulated osteoclastogenesis through a mechanism that requires CD74. In the current study, we examined if MIF modulates osteoclastogenesis through Lyn phosphorylation and if the down regulation of RANKL-mediated signaling requires the association of CD74, CD44 and Lyn. Methods: CD74 knockout, CD44 knockout and Lyn knockout mouse models were used to investigate if Lyn requires these receptor and coreceptor. Effects of MIF on osteoclastogenesis were assessed using western blot analysis, siRNA targeted downregulation of Lyn and LynKO mice and real time imaging of Lyn molecules to surface proteins. Results: MIF treatment induced Lyn expression and MIF down-regulated the RANKL-induced AP-1 and Syk-PCL? cascade during osteoclastogenesis through activated Lyn tyrosine kinase. We also found by immunoprecipitation studies that MIF receptor(s) associated with Lyn in response to MIF treatment. Studies using siRNA specific for Lyn and LynKO mice confirmed our finding. Conclusions: Our findings indicate that the tyrosine kinase, Lyn, is activated when MIF binds to its receptor, CD74 and co-receptor, CD44 and, in turn, down regulates the RANKL-mediated signaling cascade by suppressing NFATc1 protein expression through downregulation of AP-1 and calcium signaling components. Twit Text FOAVip Macrophage migration inhibitory factor down-regulates the RANKL-RANK signaling pathway by activating Lyn tyrosine kinase ????Arthritis Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=24891319 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24891319 #FOAvip English Wikipedia <ref>{{Cite pmid|24891319}}</ref> Macrophage migration inhibitory factor down-regulates the RANKL-RANK signaling pathway by activating Lyn tyrosine kinase #MMPMID24891319 Mun SH; Oh D; Lee SK Arthritis Rheumatol 2014[Sep]; 66 (9): 2482-93 PMID24891319show ga Objective: Macrophage migration inhibitory factor (MIF) is an important modulator of innate and adaptive immunity as well as local inflammatory response. We previously reported that MIF down-regulated osteoclastogenesis through a mechanism that requires CD74. In the current study, we examined if MIF modulates osteoclastogenesis through Lyn phosphorylation and if the down regulation of RANKL-mediated signaling requires the association of CD74, CD44 and Lyn. Methods: CD74 knockout, CD44 knockout and Lyn knockout mouse models were used to investigate if Lyn requires these receptor and coreceptor. Effects of MIF on osteoclastogenesis were assessed using western blot analysis, siRNA targeted downregulation of Lyn and LynKO mice and real time imaging of Lyn molecules to surface proteins. Results: MIF treatment induced Lyn expression and MIF down-regulated the RANKL-induced AP-1 and Syk-PCL? cascade during osteoclastogenesis through activated Lyn tyrosine kinase. We also found by immunoprecipitation studies that MIF receptor(s) associated with Lyn in response to MIF treatment. Studies using siRNA specific for Lyn and LynKO mice confirmed our finding. Conclusions: Our findings indicate that the tyrosine kinase, Lyn, is activated when MIF binds to its receptor, CD74 and co-receptor, CD44 and, in turn, down regulates the RANKL-mediated signaling cascade by suppressing NFATc1 protein expression through downregulation of AP-1 and calcium signaling components. äMacrophage migration inhibitory factor down-regulates the RANKL-RANK s(epmc).pdf DeepDyve Pubget Overpricing