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10.1111/cmi.12305 http://scihub22266oqcxt.onion/10.1111/cmi.12305 C4146656!4146656 !24779413     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24779413 &cmd=llinks): Failed to open stream: HTTP request failed! 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The focal complex of epithelial cells provides a signalling platform for interleukin-8 induction in response to bacterial pathogens |pdf=|usr=}}{{24779413 }} gab.com Text The focal complex of epithelial cells provides a signalling platform for interleukin-8 induction in response to bacterial pathogens JO: Cell Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=24779413 #FOAvip Bacterial pathogens can induce an inflammatory response from epithelial tissues due to secretion of the pro-inflammatory chemokine interleukin-8 (IL-8). Many bacterial pathogens manipulate components of the focal complex (FC) to induce signalling events in host cells. We examined the interaction of several bacterial pathogens with host cells, including Campylobacter jejuni, to determine if the FC is required for induction of chemokine signalling in response to bacterial pathogens. Our data indicate that secretion of IL-8 is triggered by C. jejuni, Helicobacter pylori and Salmonella enterica serovar Typhimurium in response to engagement of ?1 integrins. Additionally, we found that the secretion of IL-8 from C. jejuni infected epithelial cells requires FAK, Src and paxillin, which in turn are necessary for Erk 1/2 recruitment and activation. Targeting the FC component paxillin with siRNA prevented IL-8 secretion from cells infected with several bacterial pathogens, including C. jejuni, Helicobacter pylori, Salmonella enterica serovar Typhimurium, Staphylococcus aureus, Pseudomonas aeruginosa, and Vibrio parahaemolyticus. Our findings indicate that maximal IL-8 secretion from epithelial cells in response to bacterial infection is dependent on the FC. Based on the commonality of the host response to bacterial pathogens, we propose that the FC is a signalling platform for an epithelial cell response to pathogenic organisms. Twit Text FOAVip The focal complex of epithelial cells provides a signalling platform for interleukin-8 induction in response to bacterial pathogens ????Cell Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=24779413 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24779413 #FOAvip English Wikipedia <ref>{{Cite pmid|24779413 }}</ref> The focal complex of epithelial cells provides a signalling platform for interleukin-8 induction in response to bacterial pathogens #MMPMID24779413 Eucker TP ; Samuelson DR ; Hunzicker-Dunn M ; Konkel ME Cell Microbiol 2014[Sep]; 16 (9 ): 1441-55 PMID24779413 show ga Bacterial pathogens can induce an inflammatory response from epithelial tissues due to secretion of the pro-inflammatory chemokine interleukin-8 (IL-8). Many bacterial pathogens manipulate components of the focal complex (FC) to induce signalling events in host cells. We examined the interaction of several bacterial pathogens with host cells, including Campylobacter jejuni, to determine if the FC is required for induction of chemokine signalling in response to bacterial pathogens. Our data indicate that secretion of IL-8 is triggered by C. jejuni, Helicobacter pylori and Salmonella enterica serovar Typhimurium in response to engagement of ?1 integrins. Additionally, we found that the secretion of IL-8 from C. jejuni infected epithelial cells requires FAK, Src and paxillin, which in turn are necessary for Erk 1/2 recruitment and activation. Targeting the FC component paxillin with siRNA prevented IL-8 secretion from cells infected with several bacterial pathogens, including C. jejuni, Helicobacter pylori, Salmonella enterica serovar Typhimurium, Staphylococcus aureus, Pseudomonas aeruginosa, and Vibrio parahaemolyticus. Our findings indicate that maximal IL-8 secretion from epithelial cells in response to bacterial infection is dependent on the FC. Based on the commonality of the host response to bacterial pathogens, we propose that the FC is a signalling platform for an epithelial cell response to pathogenic organisms. |Caco-2 Cells [MESH] |Campylobacter jejuni/*immunology [MESH] |Cell Line [MESH] |Epithelial Cells/*immunology/*microbiology [MESH] |Gram-Negative Bacterial Infections/*immunology/microbiology [MESH] |Helicobacter pylori/physiology [MESH] |Humans [MESH] |Integrin beta Chains/metabolism [MESH] |Interleukin-8/*immunology [MESH]The focal complex of epithelial cells provides a signalling platform f(epmc).pdf DeepDyve Pubget Overpricing