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10.1007/s00280-014-2518-5 http://scihub22266oqcxt.onion/10.1007/s00280-014-2518-5 C4146643!4146643 !25023489     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25023489 &cmd=llinks): Failed to open stream: HTTP request failed! 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Phase Ib study of dovitinib in combination with gemcitabine plus cisplatin or gemcitabine plus carboplatin in patients with advanced solid tumors |pdf=|usr=}}{{25023489 }} gab.com Text Phase Ib study of dovitinib in combination with gemcitabine plus cisplatin or gemcitabine plus carboplatin in patients with advanced solid tumors JO: Cancer Chemother Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25023489 #FOAvip PURPOSE: Dovitinib is a small molecule kinase inhibitor with activity against the fibroblast growth factor and vascular endothelial growth factor receptor families. The purpose of this phase Ib study was to define the recommended phase 2 dose of the combinations of gemcitabine and cisplatin or gemcitabine and carboplatin plus dovitinib. METHODS: Patients with advanced solid tumors were enrolled in two parallel dose escalation arms (cisplatin- or carboplatin-based regimens). Treatment was administered with gemcitabine (1,000 mg/m(2) on days 1 and 8), cisplatin (70 mg/m(2)), or carboplatin (AUC 5) on day 1, and dovitinib (orally on days 1-5, 8-12, and 15-19), every 21 days. The starting dose of dovitinib was 300 mg and was dose escalated in successive cohorts using 3 + 3 dose escalation rules. RESULTS: Fourteen patients with advanced solid tumors were enrolled, five to the cisplatin arm and nine to the carboplatin arm. Patients enrolled in the cisplatin arm received a median of two cycles of treatment (range 1-5), and patients enrolled in the carboplatin arm received a median of one cycle of treatment (range 1-4). There were no protocol-defined dose-limiting toxicities in the cisplatin arm. However, the cohort was closed due to the need for frequent dose delays and/or reductions and two patients experiencing severe thromboembolic events. There were two dose-limiting toxicities in the carboplatin arm at the starting dose level of dovitinib (both prolonged neutropenia), and the dose of dovitinib was de-escalated to 200 mg. Two additional dose-limiting toxicities (prolonged neutropenia and febrile neutropenia) occurred in the lower dose cohort, and the study was closed. No patients achieved an objective response to treatment. CONCLUSIONS: Dovitinib in combination with gemcitabine plus cisplatin or gemcitabine plus carboplatin was poorly tolerated due to myelosuppression. Twit Text FOAVip Phase Ib study of dovitinib in combination with gemcitabine plus cisplatin or gemcitabine plus carboplatin in patients with advanced solid tumors ????Cancer Chemother Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25023489 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25023489 #FOAvip English Wikipedia <ref>{{Cite pmid|25023489 }}</ref> Phase Ib study of dovitinib in combination with gemcitabine plus cisplatin or gemcitabine plus carboplatin in patients with advanced solid tumors #MMPMID25023489 Galsky MD ; Posner M ; Holcombe RF ; Lee KM ; Misiukiewicz K ; Tsao CK ; Godbold J ; Soto R ; Gimpel-Tetra K ; Lowe N ; Oh WK Cancer Chemother Pharmacol 2014[Sep]; 74 (3 ): 465-71 PMID25023489 show ga PURPOSE: Dovitinib is a small molecule kinase inhibitor with activity against the fibroblast growth factor and vascular endothelial growth factor receptor families. The purpose of this phase Ib study was to define the recommended phase 2 dose of the combinations of gemcitabine and cisplatin or gemcitabine and carboplatin plus dovitinib. METHODS: Patients with advanced solid tumors were enrolled in two parallel dose escalation arms (cisplatin- or carboplatin-based regimens). Treatment was administered with gemcitabine (1,000 mg/m(2) on days 1 and 8), cisplatin (70 mg/m(2)), or carboplatin (AUC 5) on day 1, and dovitinib (orally on days 1-5, 8-12, and 15-19), every 21 days. The starting dose of dovitinib was 300 mg and was dose escalated in successive cohorts using 3 + 3 dose escalation rules. RESULTS: Fourteen patients with advanced solid tumors were enrolled, five to the cisplatin arm and nine to the carboplatin arm. Patients enrolled in the cisplatin arm received a median of two cycles of treatment (range 1-5), and patients enrolled in the carboplatin arm received a median of one cycle of treatment (range 1-4). There were no protocol-defined dose-limiting toxicities in the cisplatin arm. However, the cohort was closed due to the need for frequent dose delays and/or reductions and two patients experiencing severe thromboembolic events. There were two dose-limiting toxicities in the carboplatin arm at the starting dose level of dovitinib (both prolonged neutropenia), and the dose of dovitinib was de-escalated to 200 mg. Two additional dose-limiting toxicities (prolonged neutropenia and febrile neutropenia) occurred in the lower dose cohort, and the study was closed. No patients achieved an objective response to treatment. CONCLUSIONS: Dovitinib in combination with gemcitabine plus cisplatin or gemcitabine plus carboplatin was poorly tolerated due to myelosuppression. |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Antineoplastic Combined Chemotherapy Protocols/*therapeutic use [MESH] |Benzimidazoles/*administration & dosage/*adverse effects/pharmacokinetics [MESH] |Carboplatin/administration & dosage/adverse effects [MESH] |Cisplatin/administration & dosage [MESH] |Colonic Neoplasms/drug therapy/pathology [MESH] |Deoxycytidine/administration & dosage/adverse effects/analogs & derivatives [MESH] |Dose-Response Relationship, Drug [MESH] |Drug Administration Schedule [MESH] |Female [MESH] |Gemcitabine [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH] |Neoplasms/*drug therapy/pathology [MESH] |Neutropenia/chemically induced [MESH] |Quinolones/*administration & dosage/*adverse effects/pharmacokinetics [MESH] |Thromboembolism/chemically induced [MESH] |Treatment Outcome [MESH] |Urinary Bladder Neoplasms/drug therapy/pathology [MESH]Phase Ib study of dovitinib in combination with gemcitabine plus cispl(epmc).pdf DeepDyve Pubget Overpricing