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10.1016/j.mcn.2014.07.006 http://scihub22266oqcxt.onion/10.1016/j.mcn.2014.07.006 C4145808!4145808 !25066864     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25066864 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell+Neurosci 2014 ; 61 (ä): 226-40 Nephropedia Template TP {{tp|p=25066864 |t=2014. Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B |pdf=|usr=}}{{25066864 }} gab.com Text Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B JO: Mol Cell Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25066864 #FOAvip Fronto-temporal lobar degeneration with TDP-43 (FTLD-TDP) is a fatal neurodegeneration. TMEM106B variants are linked to FTLD-TDP risk, and TMEM106B is lysosomal. Here, we focus on neuronal TMEM106B, and demonstrate co-localization and traffic with lysosomal LAMP-1. pH-sensitive reporters demonstrate that the TMEM106B C-terminus is lumenal. The TMEM106B N-terminus interacts with endosomal adaptors and other TMEM106 proteins. TMEM106B knockdown reduces neuronal lysosomal number and diameter by STED microscopy, and overexpression enlarges LAMP-positive structures. Reduction of TMEM106B increases axonally transported lysosomes, while TMEM106B elevation inhibits transport and yields large lysosomes in the soma. TMEM106B overexpression alters lysosomal stress signaling, causing a translocation of the mTOR-sensitive transcription factor, TFEB, to neuronal nuclei. TMEM106B loss-of-function delays TFEB translocation after Torin-1-induced stress. Enlarged TMEM106B-overexpressing lysosomes maintain organelle integrity longer after lysosomal photodamage than do control lysosomes, while small TMEM106B-knockdown lysosomes are more sensitive to illumination. Thus, neuronal TMEM106B plays a central role in regulating lysosomal size, motility and responsiveness to stress, highlighting the possible role of lysosomal biology in FTLD-TDP. Twit Text FOAVip Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B ????Mol Cell Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25066864 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25066864 #FOAvip English Wikipedia <ref>{{Cite pmid|25066864 }}</ref> Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B #MMPMID25066864 Stagi M ; Klein ZA ; Gould TJ ; Bewersdorf J ; Strittmatter SM Mol Cell Neurosci 2014[Jul]; 61 (ä): 226-40 PMID25066864 show ga Fronto-temporal lobar degeneration with TDP-43 (FTLD-TDP) is a fatal neurodegeneration. TMEM106B variants are linked to FTLD-TDP risk, and TMEM106B is lysosomal. Here, we focus on neuronal TMEM106B, and demonstrate co-localization and traffic with lysosomal LAMP-1. pH-sensitive reporters demonstrate that the TMEM106B C-terminus is lumenal. The TMEM106B N-terminus interacts with endosomal adaptors and other TMEM106 proteins. TMEM106B knockdown reduces neuronal lysosomal number and diameter by STED microscopy, and overexpression enlarges LAMP-positive structures. Reduction of TMEM106B increases axonally transported lysosomes, while TMEM106B elevation inhibits transport and yields large lysosomes in the soma. TMEM106B overexpression alters lysosomal stress signaling, causing a translocation of the mTOR-sensitive transcription factor, TFEB, to neuronal nuclei. TMEM106B loss-of-function delays TFEB translocation after Torin-1-induced stress. Enlarged TMEM106B-overexpressing lysosomes maintain organelle integrity longer after lysosomal photodamage than do control lysosomes, while small TMEM106B-knockdown lysosomes are more sensitive to illumination. Thus, neuronal TMEM106B plays a central role in regulating lysosomal size, motility and responsiveness to stress, highlighting the possible role of lysosomal biology in FTLD-TDP. |Animals [MESH] |Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics/metabolism [MESH] |Cells, Cultured [MESH] |Chlorocebus aethiops [MESH] |Embryo, Mammalian [MESH] |Green Fluorescent Proteins/genetics/metabolism [MESH] |Humans [MESH] |Luminescent Proteins/metabolism [MESH] |Lysosomal-Associated Membrane Protein 1/metabolism [MESH] |Lysosomes/*metabolism [MESH] |Membrane Proteins/genetics/*metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Microtubule-Associated Proteins [MESH] |Nerve Tissue Proteins/genetics/*metabolism [MESH] |Protein Transport/*genetics [MESH] |RNA, Messenger/metabolism [MESH] |RNA, Small Interfering/metabolism [MESH] |Red Fluorescent Protein [MESH] |Stress, Physiological/*genetics [MESH]Lysosome size, motility and stress response regulated by fronto-tempor(epmc).pdf DeepDyve Pubget Overpricing