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10.4049/jimmunol.1300237 http://scihub22266oqcxt.onion/10.4049/jimmunol.1300237 C4144807!4144807 !24591364     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24591364 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2014 ; 192 (7 ): 3374-82 Nephropedia Template TP {{tp|p=24591364 |t=2014. Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophils |pdf=|usr=}}{{24591364 }} gab.com Text Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophils JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24591364 #FOAvip Neutrophils are the most abundant cell type in the immune system and play an important role in the innate immune response. Using a diverse range of mouse models with either defective dendritic cell (DC) development or conditional DC depletion, we provide in vivo evidence indicating that conventional DCs play an important role in the regulation of neutrophil homeostasis. Flk2, Flt3L, and Batf3 knockout mice, which have defects in DC development, have increased numbers of liver neutrophils in the steady state. Conversely, neutrophil frequency is reduced in DC-specific PTEN knockout mice, which have an expansion of CD8(+) and CD103(+) DCs. In chimeric CD11c-DTR mice, conventional DC depletion results in a systemic increase of neutrophils in peripheral organs in the absence of histological inflammation or an increase in proinflammatory cytokines. This effect is also present in splenectomized chimeric CD11c-DTR mice and is absent in chimeric mice with 50% normal bone marrow. In chimeric CD11c-DTR mice, diphtheria toxin treatment results in enhanced neutrophil trafficking from the bone marrow into circulation and increased neutrophil recruitment. Moreover, there is an increased expression of chemokines/cytokines involved in neutrophil homeostasis and reduced neutrophil apoptosis. These data underscore the role of the DC pool in regulating the neutrophil compartment in nonlymphoid organs. Twit Text FOAVip Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophils ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24591364 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24591364 #FOAvip English Wikipedia <ref>{{Cite pmid|24591364 }}</ref> Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophils #MMPMID24591364 Jiao J ; Dragomir AC ; Kocabayoglu P ; Rahman AH ; Chow A ; Hashimoto D ; Leboeuf M ; Kraus T ; Moran T ; Carrasco-Avino G ; Friedman SL ; Merad M ; Aloman C J Immunol 2014[Apr]; 192 (7 ): 3374-82 PMID24591364 show ga Neutrophils are the most abundant cell type in the immune system and play an important role in the innate immune response. Using a diverse range of mouse models with either defective dendritic cell (DC) development or conditional DC depletion, we provide in vivo evidence indicating that conventional DCs play an important role in the regulation of neutrophil homeostasis. Flk2, Flt3L, and Batf3 knockout mice, which have defects in DC development, have increased numbers of liver neutrophils in the steady state. Conversely, neutrophil frequency is reduced in DC-specific PTEN knockout mice, which have an expansion of CD8(+) and CD103(+) DCs. In chimeric CD11c-DTR mice, conventional DC depletion results in a systemic increase of neutrophils in peripheral organs in the absence of histological inflammation or an increase in proinflammatory cytokines. This effect is also present in splenectomized chimeric CD11c-DTR mice and is absent in chimeric mice with 50% normal bone marrow. In chimeric CD11c-DTR mice, diphtheria toxin treatment results in enhanced neutrophil trafficking from the bone marrow into circulation and increased neutrophil recruitment. Moreover, there is an increased expression of chemokines/cytokines involved in neutrophil homeostasis and reduced neutrophil apoptosis. These data underscore the role of the DC pool in regulating the neutrophil compartment in nonlymphoid organs. |Animals [MESH] |Apoptosis/genetics/immunology [MESH] |Basic-Leucine Zipper Transcription Factors/deficiency/genetics/immunology [MESH] |Bone Marrow Transplantation [MESH] |Bone Marrow/*immunology/metabolism [MESH] |CD11c Antigen/genetics/immunology/metabolism [MESH] |Cell Survival/genetics/immunology [MESH] |Cytokines/immunology/metabolism [MESH] |Dendritic Cells/*immunology/metabolism [MESH] |Female [MESH] |Flow Cytometry [MESH] |Heparin-binding EGF-like Growth Factor [MESH] |Homeostasis/genetics/*immunology [MESH] |Inflammation Mediators/immunology/metabolism [MESH] |Intercellular Signaling Peptides and Proteins/genetics/immunology/metabolism [MESH] |Liver/immunology/metabolism [MESH] |Membrane Proteins/deficiency/genetics/immunology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |Microscopy, Confocal [MESH] |Neutrophils/*immunology/metabolism [MESH] |PTEN Phosphohydrolase/deficiency/genetics/immunology [MESH] |Repressor Proteins/deficiency/genetics/immunology [MESH]Central role of conventional dendritic cells in regulation of bone mar(epmc).pdf DeepDyve Pubget Overpricing