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10.1093/neuonc/nou206.50 http://scihub22266oqcxt.onion/10.1093/neuonc/nou206.50 C4144518/?report=reader!4144518!C4144518     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuro+Oncol 2014 ; 16 (Suppl 3): iii14 Nephropedia Template TP {{tp|p=C4144518|t=2014. GLIOBLASTOMA STEM CELL-DERIVED PERICYTES AND TUMOR ANGIOGENESIS |pdf=|usr=}}{{C4144518}} gab.com Text GLIOBLASTOMA STEM CELL-DERIVED PERICYTES AND TUMOR ANGIOGENESIS JO: Neuro Oncol http://www.kidney.de/pget.php?&tw=1&pmid=C4144518 #FOAvip BACKGROUND: Glioblastoma (GBM) is the most lethal type of primary brain tumor with florid angiogenesis. GBMs display striking cellular hierarchies containing self-renewing glioma stem cells (GSCs) that are highly tumorigenic. GSCs not only produce elevated levels of VEGF to promote tumor angiogenesis but also contribute to cellular compartments of tumor vessels. METHODS: 1. In vivo cell lineage tracing with constitutive and Desmin promoter-driven GFP or RFP fluorescent reporters. 2. Selective elimination of GSC-derived pericytes with Desmin promoter-driven HsvTK. 3. GSC-derived GBM xenograft models. RESULTS: Cell lineage tracing with constitutive and lineage specific fluorescent reporters demonstrated that GSCs generate the majority of vascular pericytes in vivo. Selective elimination of GSC-derived pericytes disrupted tumor vessels and potently suppressed GSC tumor growth. Thus, GSCs can function as pericyte progenitors and contribute to vasculature formation and maintenance in GBMs. CONCLUSIONS: The ability of GSCs to generate the majority of pericytes allows active tumor angiogenesis to promote rapid tumor growth in GBMs. GSC-derived pericytes also play a critical role in the resistance to the anti-angiogenic therapy targeting endothelial cells only, suggesting that selective targeting of GSC-derived pericytes may significantly improve the efficacy and specificity of the anti-angiogenic treatment. SECONDARY CATEGORY: n/a. Twit Text FOAVip GLIOBLASTOMA STEM CELL-DERIVED PERICYTES AND TUMOR ANGIOGENESIS ????Neuro Oncol http://www.kidney.de/pget.php?&tw=1&pmid=C4144518 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=C4144518 #FOAvip English Wikipedia <ref>{{Cite pmid|C4144518}}</ref> GLIOBLASTOMA STEM CELL-DERIVED PERICYTES AND TUMOR ANGIOGENESIS #MMPMIDC4144518 Bao S; Cheng L; Huang Z; Zhou W; Wu Q; Rich JN Neuro Oncol 2014[Jul]; 16 (Suppl 3): iii14 PMIDC4144518show ga BACKGROUND: Glioblastoma (GBM) is the most lethal type of primary brain tumor with florid angiogenesis. GBMs display striking cellular hierarchies containing self-renewing glioma stem cells (GSCs) that are highly tumorigenic. GSCs not only produce elevated levels of VEGF to promote tumor angiogenesis but also contribute to cellular compartments of tumor vessels. METHODS: 1. In vivo cell lineage tracing with constitutive and Desmin promoter-driven GFP or RFP fluorescent reporters. 2. Selective elimination of GSC-derived pericytes with Desmin promoter-driven HsvTK. 3. GSC-derived GBM xenograft models. RESULTS: Cell lineage tracing with constitutive and lineage specific fluorescent reporters demonstrated that GSCs generate the majority of vascular pericytes in vivo. Selective elimination of GSC-derived pericytes disrupted tumor vessels and potently suppressed GSC tumor growth. Thus, GSCs can function as pericyte progenitors and contribute to vasculature formation and maintenance in GBMs. CONCLUSIONS: The ability of GSCs to generate the majority of pericytes allows active tumor angiogenesis to promote rapid tumor growth in GBMs. GSC-derived pericytes also play a critical role in the resistance to the anti-angiogenic therapy targeting endothelial cells only, suggesting that selective targeting of GSC-derived pericytes may significantly improve the efficacy and specificity of the anti-angiogenic treatment. SECONDARY CATEGORY: n/a. äGLIOBLASTOMA STEM CELL-DERIVED PERICYTES AND TUMOR ANGIOGENESIS (epmc).pdf DeepDyve Pubget Overpricing