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10.1016/j.biomaterials.2014.07.005 http://scihub22266oqcxt.onion/10.1016/j.biomaterials.2014.07.005 C4144416!4144416!25047625     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomaterials 2014 ; 35 (31): 8820-8 Nephropedia Template TP {{tp|p=25047625|t=2014. Discrete Microstructural Cues for the Attenuation of Fibrosis Following Myocardial Infarction |pdf=|usr=}}{{25047625}} gab.com Text Discrete Microstructural Cues for the Attenuation of Fibrosis Following Myocardial Infarction JO: Biomaterials http://www.kidney.de/pget.php?&tw=1&pmid=25047625 #FOAvip Chronic fibrosis caused by acute myocardial infarction (MI) leads to increased morbidity and mortality due to cardiac dysfunction. We have developed a therapeutic materials strategy that aims to mitigate myocardial fibrosis by utilizing injectable polymeric microstructures to mechanically alter the microenvironment. Polymeric microstructures were fabricated using photolithographic techniques and studied in a three-dimensional culture model of the fibrotic environment and by direct injection into the infarct zone of adult rats. Here, we show dose-dependent down-regulation of expression of genes associated with the mechanical fibrotic response in the presence of microstructures. Injection of this microstructured material into the infarct zone decreased levels of collagen and TGF-?, increased elastin deposition and vascularization in the infarcted region, and improved functional outcomes after six weeks. Our results demonstrate the efficacy of these discrete anti-fibrotic microstructures and suggest a potential therapeutic materials approach for combatting pathologic fibrosis. Twit Text FOAVip Discrete Microstructural Cues for the Attenuation of Fibrosis Following Myocardial Infarction ????Biomaterials http://www.kidney.de/pget.php?&tw=1&pmid=25047625 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25047625 #FOAvip English Wikipedia <ref>{{Cite pmid|25047625}}</ref> Discrete Microstructural Cues for the Attenuation of Fibrosis Following Myocardial Infarction #MMPMID25047625 Pinney JR; Du K; Ayala P; Fang Q; Sievers R; Chew P; Delrosario L; Lee RJ; Desai TA Biomaterials 2014[Oct]; 35 (31): 8820-8 PMID25047625show ga Chronic fibrosis caused by acute myocardial infarction (MI) leads to increased morbidity and mortality due to cardiac dysfunction. We have developed a therapeutic materials strategy that aims to mitigate myocardial fibrosis by utilizing injectable polymeric microstructures to mechanically alter the microenvironment. Polymeric microstructures were fabricated using photolithographic techniques and studied in a three-dimensional culture model of the fibrotic environment and by direct injection into the infarct zone of adult rats. Here, we show dose-dependent down-regulation of expression of genes associated with the mechanical fibrotic response in the presence of microstructures. Injection of this microstructured material into the infarct zone decreased levels of collagen and TGF-?, increased elastin deposition and vascularization in the infarcted region, and improved functional outcomes after six weeks. Our results demonstrate the efficacy of these discrete anti-fibrotic microstructures and suggest a potential therapeutic materials approach for combatting pathologic fibrosis. äDiscrete Microstructural Cues for the Attenuation of Fibrosis Followin(epmc).pdf DeepDyve Pubget Overpricing