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10.1039/c3cs60459d http://scihub22266oqcxt.onion/10.1039/c3cs60459d C4143503!4143503 !24566672     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24566672 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Chem+Soc+Rev 2014 ; 43 (19 ): 6750-64 Nephropedia Template TP {{tp|p=24566672 |t=2014. Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs |pdf=|usr=}}{{24566672 }} gab.com Text Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs JO: Chem Soc Rev http://www.kidney.de/pget.php?&tw=1&pmid=24566672 #FOAvip Aggregation of disordered amyloidogenic peptides into oligomers is the causative agent of amyloid-related diseases. In solution, disordered protein states are characterized by heterogeneous ensembles. Among these, ?-rich conformers self-assemble via a conformational selection mechanism to form energetically-favored cross-? structures, regardless of their precise sequences. These disordered peptides can also penetrate the membrane, and electrophysiological data indicate that they form ion-conducting channels. Based on these and additional data, including imaging and molecular dynamics simulations of a range of amyloid peptides, Alzheimer's amyloid-? (A?) peptide, its disease-related variants with point mutations and N-terminal truncated species, other amyloidogenic peptides, as well as a cytolytic peptide and a synthetic gel-forming peptide, we suggest that disordered amyloidogenic peptides can also present a common motif in the membrane. The motif consists of curved, moon-like ?-rich oligomers associated into annular organizations. The motif is favored in the lipid bilayer since it permits hydrophobic side chains to face and interact with the membrane and the charged/polar residues to face the solvated channel pores. Such channels are toxic since their pores allow uncontrolled leakage of ions into/out of the cell, destabilizing cellular ionic homeostasis. Here we detail A?, whose aggregation is associated with Alzheimer's disease (AD) and for which there are the most abundant data. AD is a protein misfolding disease characterized by a build-up of A? peptide as senile plaques, neurodegeneration, and memory loss. Excessively produced A? peptides may directly induce cellular toxicity, even without the involvement of membrane receptors through A? peptide-plasma membrane interactions. Twit Text FOAVip Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs ????Chem Soc Rev http://www.kidney.de/pget.php?&tw=1&pmid=24566672 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24566672 #FOAvip English Wikipedia <ref>{{Cite pmid|24566672 }}</ref> Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs #MMPMID24566672 Jang H ; Arce FT ; Ramachandran S ; Kagan BL ; Lal R ; Nussinov R Chem Soc Rev 2014[Oct]; 43 (19 ): 6750-64 PMID24566672 show ga Aggregation of disordered amyloidogenic peptides into oligomers is the causative agent of amyloid-related diseases. In solution, disordered protein states are characterized by heterogeneous ensembles. Among these, ?-rich conformers self-assemble via a conformational selection mechanism to form energetically-favored cross-? structures, regardless of their precise sequences. These disordered peptides can also penetrate the membrane, and electrophysiological data indicate that they form ion-conducting channels. Based on these and additional data, including imaging and molecular dynamics simulations of a range of amyloid peptides, Alzheimer's amyloid-? (A?) peptide, its disease-related variants with point mutations and N-terminal truncated species, other amyloidogenic peptides, as well as a cytolytic peptide and a synthetic gel-forming peptide, we suggest that disordered amyloidogenic peptides can also present a common motif in the membrane. The motif consists of curved, moon-like ?-rich oligomers associated into annular organizations. The motif is favored in the lipid bilayer since it permits hydrophobic side chains to face and interact with the membrane and the charged/polar residues to face the solvated channel pores. Such channels are toxic since their pores allow uncontrolled leakage of ions into/out of the cell, destabilizing cellular ionic homeostasis. Here we detail A?, whose aggregation is associated with Alzheimer's disease (AD) and for which there are the most abundant data. AD is a protein misfolding disease characterized by a build-up of A? peptide as senile plaques, neurodegeneration, and memory loss. Excessively produced A? peptides may directly induce cellular toxicity, even without the involvement of membrane receptors through A? peptide-plasma membrane interactions. |Alzheimer Disease/metabolism/pathology [MESH] |Amyloid beta-Peptides/chemistry/*metabolism [MESH] |Cell Membrane/chemistry/*metabolism [MESH] |Humans [MESH] |Hydrophobic and Hydrophilic Interactions [MESH] |Lipid Bilayers/chemistry/metabolism [MESH] |Molecular Dynamics Simulation [MESH]Disordered amyloidogenic peptides may insert into the membrane and ass(epmc).pdf DeepDyve Pubget Overpricing