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10.1016/j.immuni.2014.04.020 http://scihub22266oqcxt.onion/10.1016/j.immuni.2014.04.020 C4143255!4143255!24909888     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2014 ; 40 (6): 910-23 Nephropedia Template TP {{tp|p=24909888|t=2014. Activated T cells secrete an alternatively spliced form of ?c that inhibits cytokine signaling and exacerbates inflammatory autoimmune disease |pdf=|usr=}}{{24909888}} gab.com Text Activated T cells secrete an alternatively spliced form of c that inhibits cytokine signaling and exacerbates inflammatory autoimmune disease JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=24909888 #FOAvip The common ?-chain (?c) plays a central role in signaling by IL-2 and other ?c?dependent cytokines. Here we report that activated T cells produce an alternatively spliced form of ?c mRNA that results in protein expression and secretion of the ?c extracellular domain. The soluble form of ?c (s?c) is present in serum and directly binds to IL-2R? and IL-7R? proteins on T cells to inhibit cytokine signaling and promote inflammation. S?c suppressed IL-7 signaling to impair naïve T cell survival during homeostasis and exacerbated Th17-cell-mediated inflammation by inhibiting IL-2 signaling upon T cell activation. Reciprocally, the severity of Th17-cell-mediated inflammatory diseases was markedly diminished in mice lacking s?c. Thus, s?c expression is a naturally occurring immunomodulator that regulates ?c cytokine signaling and controls T cell activation and differentiation. Twit Text FOAVip Activated T cells secrete an alternatively spliced form of c that inhibits cytokine signaling and exacerbates inflammatory autoimmune disease ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=24909888 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24909888 #FOAvip English Wikipedia <ref>{{Cite pmid|24909888}}</ref> Activated T cells secrete an alternatively spliced form of ?c that inhibits cytokine signaling and exacerbates inflammatory autoimmune disease #MMPMID24909888 Hong C; Luckey MA; Ligons DL; Waickman AT; Park JY; Kim GY; Keller HR; Etzensperger R; Tai X; Lazarevic V; Feigenbaum L; Catalfamo M; Walsh STR; Park JH Immunity 2014[Jun]; 40 (6): 910-23 PMID24909888show ga The common ?-chain (?c) plays a central role in signaling by IL-2 and other ?c?dependent cytokines. Here we report that activated T cells produce an alternatively spliced form of ?c mRNA that results in protein expression and secretion of the ?c extracellular domain. The soluble form of ?c (s?c) is present in serum and directly binds to IL-2R? and IL-7R? proteins on T cells to inhibit cytokine signaling and promote inflammation. S?c suppressed IL-7 signaling to impair naïve T cell survival during homeostasis and exacerbated Th17-cell-mediated inflammation by inhibiting IL-2 signaling upon T cell activation. Reciprocally, the severity of Th17-cell-mediated inflammatory diseases was markedly diminished in mice lacking s?c. Thus, s?c expression is a naturally occurring immunomodulator that regulates ?c cytokine signaling and controls T cell activation and differentiation. äActivated T cells secrete an alternatively spliced form of ?c that inh(epmc).pdf DeepDyve Pubget Overpricing