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10.1016/j.immuni.2014.04.020 http://scihub22266oqcxt.onion/10.1016/j.immuni.2014.04.020 C4143255!4143255 !24909888     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24909888 &cmd=llinks): Failed to open stream: HTTP request failed! 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Activated T cells secrete an alternatively spliced form of common ?-chain that inhibits cytokine signaling and exacerbates inflammation |pdf=|usr=}}{{24909888 }} gab.com Text Activated T cells secrete an alternatively spliced form of common -chain that inhibits cytokine signaling and exacerbates inflammation JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=24909888 #FOAvip The common ?-chain (?c) plays a central role in signaling by IL-2 and other ?c-dependent cytokines. Here we report that activated T cells produce an alternatively spliced form of ?c mRNA that results in protein expression and secretion of the ?c extracellular domain. The soluble form of ?c (s?c) is present in serum and directly binds to IL-2R? and IL-7R? proteins on T cells to inhibit cytokine signaling and promote inflammation. s?c suppressed IL-7 signaling to impair naive T cell survival during homeostasis and exacerbated Th17-cell-mediated inflammation by inhibiting IL-2 signaling upon T cell activation. Reciprocally, the severity of Th17-cell-mediated inflammatory diseases was markedly diminished in mice lacking s?c. Thus, s?c expression is a naturally occurring immunomodulator that regulates ?c cytokine signaling and controls T cell activation and differentiation. Twit Text FOAVip Activated T cells secrete an alternatively spliced form of common -chain that inhibits cytokine signaling and exacerbates inflammation ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=24909888 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24909888 #FOAvip English Wikipedia <ref>{{Cite pmid|24909888 }}</ref> Activated T cells secrete an alternatively spliced form of common ?-chain that inhibits cytokine signaling and exacerbates inflammation #MMPMID24909888 Hong C ; Luckey MA ; Ligons DL ; Waickman AT ; Park JY ; Kim GY ; Keller HR ; Etzensperger R ; Tai X ; Lazarevic V ; Feigenbaum L ; Catalfamo M ; Walsh ST ; Park JH Immunity 2014[Jun]; 40 (6 ): 910-23 PMID24909888 show ga The common ?-chain (?c) plays a central role in signaling by IL-2 and other ?c-dependent cytokines. Here we report that activated T cells produce an alternatively spliced form of ?c mRNA that results in protein expression and secretion of the ?c extracellular domain. The soluble form of ?c (s?c) is present in serum and directly binds to IL-2R? and IL-7R? proteins on T cells to inhibit cytokine signaling and promote inflammation. s?c suppressed IL-7 signaling to impair naive T cell survival during homeostasis and exacerbated Th17-cell-mediated inflammation by inhibiting IL-2 signaling upon T cell activation. Reciprocally, the severity of Th17-cell-mediated inflammatory diseases was markedly diminished in mice lacking s?c. Thus, s?c expression is a naturally occurring immunomodulator that regulates ?c cytokine signaling and controls T cell activation and differentiation. |Alternative Splicing/*immunology [MESH] |Animals [MESH] |Autoimmunity [MESH] |Cell Differentiation/immunology [MESH] |Cell Proliferation [MESH] |Cell Survival/immunology [MESH] |Encephalomyelitis, Autoimmune, Experimental/*immunology [MESH] |Immunoglobulin gamma-Chains/blood/genetics/*immunology [MESH] |Immunomodulation [MESH] |Inflammation/*immunology [MESH] |Interleukin-2 Receptor beta Subunit/immunology [MESH] |Interleukin-5 Receptor alpha Subunit/immunology [MESH] |Lymphocyte Activation/immunology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Protein Binding/immunology [MESH] |Protein Isoforms/genetics/immunology [MESH] |RNA, Messenger/biosynthesis/genetics [MESH] |Signal Transduction/immunology [MESH]Activated T cells secrete an alternatively spliced form of common ?-ch(epmc).pdf DeepDyve Pubget Overpricing