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10.1101/cshperspect.a014399 http://scihub22266oqcxt.onion/10.1101/cshperspect.a014399 C4143105!4143105!24939054     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cold+Spring+Harb+Perspect+Med 2014 ; 4 (9): ä Nephropedia Template TP {{tp|p=24939054|t=2014. MYC Cofactors: Molecular Switches Controlling Diverse Biological Outcomes |pdf=|usr=}}{{24939054}} gab.com Text MYC Cofactors: Molecular Switches Controlling Diverse Biological Outcomes JO: Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=24939054 #FOAvip The transcription factor MYC has fundamental roles in proliferation, apoptosis, tumorigenesis, and stem cell pluripotency. Over the last 30 years extensive information has been gathered on the numerous cofactors that interact with MYC and the target genes that are regulated by MYC as a means of understanding the molecular mechanisms controlling its diverse roles. Despite significant advances and perhaps because the amount of information learned about MYC is overwhelming, there has been little consensus on the molecular functions of MYC that mediate its critical biological roles. In this perspective, the major MYC cofactors that regulate the various transcriptional activities of MYC, including canonical and noncanonical transactivation and transcriptional repression, will be reviewed and a model of how these transcriptional mechanisms control MYC-mediated proliferation, apoptosis, and tumorigenesis will be presented. The basis of the model is that a variety of cofactors form dynamic MYC transcriptional complexes that can switch the molecular and biological functions of MYC to yield a diverse range of outcomes in a cell-type- and context-dependent fashion. Twit Text FOAVip MYC Cofactors: Molecular Switches Controlling Diverse Biological Outcomes ????Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=24939054 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24939054 #FOAvip English Wikipedia <ref>{{Cite pmid|24939054}}</ref> MYC Cofactors: Molecular Switches Controlling Diverse Biological Outcomes #MMPMID24939054 Hann SR Cold Spring Harb Perspect Med 2014[Sep]; 4 (9): ä PMID24939054show ga The transcription factor MYC has fundamental roles in proliferation, apoptosis, tumorigenesis, and stem cell pluripotency. Over the last 30 years extensive information has been gathered on the numerous cofactors that interact with MYC and the target genes that are regulated by MYC as a means of understanding the molecular mechanisms controlling its diverse roles. Despite significant advances and perhaps because the amount of information learned about MYC is overwhelming, there has been little consensus on the molecular functions of MYC that mediate its critical biological roles. In this perspective, the major MYC cofactors that regulate the various transcriptional activities of MYC, including canonical and noncanonical transactivation and transcriptional repression, will be reviewed and a model of how these transcriptional mechanisms control MYC-mediated proliferation, apoptosis, and tumorigenesis will be presented. The basis of the model is that a variety of cofactors form dynamic MYC transcriptional complexes that can switch the molecular and biological functions of MYC to yield a diverse range of outcomes in a cell-type- and context-dependent fashion. äMYC Cofactors: Molecular Switches Controlling Diverse Biological Outco(epmc).pdf DeepDyve Pubget Overpricing