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2014 ; 6
(9
): a017004
Nephropedia Template TP
gab.com Text
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English Wikipedia
Unconventional functions for clathrin, ESCRTs, and other endocytic regulators in
the cytoskeleton, cell cycle, nucleus, and beyond: links to human disease
#MMPMID25183831
Brodsky FM
; Sosa RT
; Ybe JA
; O'Halloran TJ
Cold Spring Harb Perspect Biol
2014[Sep]; 6
(9
): a017004
PMID25183831
show ga
The roles of clathrin, its regulators, and the ESCRT (endosomal sorting complex
required for transport) proteins are well defined in endocytosis. These proteins
can also participate in intracellular pathways that are independent of
endocytosis and even independent of the membrane trafficking function of these
proteins. These nonendocytic functions involve unconventional biochemical
interactions for some endocytic regulators, but can also exploit known
interactions for nonendocytic functions. The molecular basis for the involvement
of endocytic regulators in unconventional functions that influence the
cytoskeleton, cell cycle, signaling, and gene regulation are described here.
Through these additional functions, endocytic regulators participate in pathways
that affect infection, glucose metabolism, development, and cellular
transformation, expanding their significance in human health and disease.
|Animals
[MESH]
|Apoptosis
[MESH]
|Cell Cycle
[MESH]
|Cell Division
[MESH]
|Cell Membrane/metabolism
[MESH]
|Cell Nucleus/*metabolism
[MESH]
|Clathrin/*metabolism
[MESH]
|Cytoskeleton/*metabolism
[MESH]
|Dimerization
[MESH]
|Endocytosis/*physiology
[MESH]
|Endosomal Sorting Complexes Required for Transport/*metabolism
[MESH]