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The Biogenesis of Lysosomes and Lysosome-Related Organelles #MMPMID25183830
Luzio JP; Hackmann Y; Dieckmann NM; Griffiths GM
Cold Spring Harb Perspect Biol 2014[Sep]; 6 (9): ä PMID25183830show ga
Lysosomes were once considered the end point of endocytosis, simply used for macromolecule degradation. They are now recognized to be dynamic organelles, able to fuse with a variety of targets and to be re-formed after fusion events. They are also now known to be the site of nutrient sensing and signaling to the cell nucleus. In addition, lysosomes are secretory organelles, with specialized machinery for regulated secretion of proteins in some cell types. The biogenesis of lysosomes and lysosome-related organelles is discussed, taking into account their dynamic nature and multiple roles.