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10.1016/j.molcel.2014.05.019 http://scihub22266oqcxt.onion/10.1016/j.molcel.2014.05.019 C4142594!4142594!24954905     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell 2014 ; 55 (1): 85-96 Nephropedia Template TP {{tp|p=24954905|t=2014. Cellular Noise Suppression by the Regulator of G Protein Signaling Sst2 |pdf=|usr=}}{{24954905}} gab.com Text Cellular Noise Suppression by the Regulator of G Protein Signaling Sst2 JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=24954905 #FOAvip G proteins and their associated receptors process information from a variety of environmental stimuli to induce appropriate cellular responses. Generally speaking, each cell in a population responds within defined limits despite large variation in the expression of protein signaling components. Therefore we postulated that noise suppression is encoded within the signaling system. Using the yeast mating pathway as a model we evaluated the ability of a regulator of G protein signaling (RGS) protein to suppress noise. We found that the RGS protein Sst2 limits variability in transcription and morphogenesis in response to pheromone stimulation. While signal suppression is a result of both the GAP (GTPase accelerating) and receptor binding functions of Sst2, noise suppression requires only the GAP activity. Taken together our findings reveal a hitherto overlooked role of RGS proteins as noise suppressors, and demonstrate an ability to uncouple signal and noise in a prototypical stimulus-response pathway. Twit Text FOAVip Cellular Noise Suppression by the Regulator of G Protein Signaling Sst2 ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=24954905 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24954905 #FOAvip English Wikipedia <ref>{{Cite pmid|24954905}}</ref> Cellular Noise Suppression by the Regulator of G Protein Signaling Sst2 #MMPMID24954905 Dixit G; Kelley JB; Houser JR; Elston TC; Dohlman HG Mol Cell 2014[Jul]; 55 (1): 85-96 PMID24954905show ga G proteins and their associated receptors process information from a variety of environmental stimuli to induce appropriate cellular responses. Generally speaking, each cell in a population responds within defined limits despite large variation in the expression of protein signaling components. Therefore we postulated that noise suppression is encoded within the signaling system. Using the yeast mating pathway as a model we evaluated the ability of a regulator of G protein signaling (RGS) protein to suppress noise. We found that the RGS protein Sst2 limits variability in transcription and morphogenesis in response to pheromone stimulation. While signal suppression is a result of both the GAP (GTPase accelerating) and receptor binding functions of Sst2, noise suppression requires only the GAP activity. Taken together our findings reveal a hitherto overlooked role of RGS proteins as noise suppressors, and demonstrate an ability to uncouple signal and noise in a prototypical stimulus-response pathway. äCellular Noise Suppression by the Regulator of G Protein Signaling Sst(epmc).pdf DeepDyve Pubget Overpricing