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10.1016/j.jconrel.2014.06.043 http://scihub22266oqcxt.onion/10.1016/j.jconrel.2014.06.043 C4142116!4142116!24998941     free     free     free       J+Control+Release 2014 ; ä (ä): 172-81 Nephropedia Template TP {{tp|p=24998941|t=2014. Ocular delivery of macromolecules |pdf=|usr=}}{{24998941}} gab.com Text Ocular delivery of macromolecules JO: J Control Release http://www.kidney.de/pget.php?&tw=1&pmid=24998941 #FOAvip Biopharmaceuticals are making increasing impact on medicine, including treatment of indications in the eye. Macromolecular drugs are typically given by physician-administered invasive delivery methods, because non--invasive ocular delivery methods, such as eye drops, and systemic delivery, have low bioavailability and/or poor ocular targeting. There is a need to improve delivery of biopharmaceuticals to enable less-invasive delivery routes, less-frequent dosing through controlled-release drug delivery and improved drug targeting within the eye to increase efficacy and reduce side effects. This review discusses the barriers to drug delivery via various ophthalmic routes of administration in the context of macromolecule delivery and discusses efforts to develop controlled-release systems for delivery of biopharmaceuticals to the eye. The growing number of macromolecular therapies in the eye needs improved drug delivery methods that increase drug efficacy, safety and patient compliance. Twit Text FOAVip Ocular delivery of macromolecules ????J Control Release http://www.kidney.de/pget.php?&tw=1&pmid=24998941 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24998941 #FOAvip English Wikipedia <ref>{{Cite pmid|24998941}}</ref> Ocular delivery of macromolecules #MMPMID24998941 Kim YC; Chiang B; Wu X; Prausnitz MR J Control Release 2014[Sep]; ä (ä): 172-81 PMID24998941show ga Biopharmaceuticals are making increasing impact on medicine, including treatment of indications in the eye. Macromolecular drugs are typically given by physician-administered invasive delivery methods, because non--invasive ocular delivery methods, such as eye drops, and systemic delivery, have low bioavailability and/or poor ocular targeting. There is a need to improve delivery of biopharmaceuticals to enable less-invasive delivery routes, less-frequent dosing through controlled-release drug delivery and improved drug targeting within the eye to increase efficacy and reduce side effects. This review discusses the barriers to drug delivery via various ophthalmic routes of administration in the context of macromolecule delivery and discusses efforts to develop controlled-release systems for delivery of biopharmaceuticals to the eye. The growing number of macromolecular therapies in the eye needs improved drug delivery methods that increase drug efficacy, safety and patient compliance. äOcular delivery of macromolecules (epmc).pdf DeepDyve Pubget Overpricing