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10.1016/j.mito.2014.07.002 http://scihub22266oqcxt.onion/10.1016/j.mito.2014.07.002 C4142054!4142054!25034306     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mitochondrion 2014 ; 17 (ä): 116-25 Nephropedia Template TP {{tp|p=25034306|t=2014. High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects |pdf=|usr=}}{{25034306}} gab.com Text High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects JO: Mitochondrion http://www.kidney.de/pget.php?&tw=1&pmid=25034306 #FOAvip Repurposing of FDA-approved drugs with effects on mitochondrial function might shorten the critical path to mitochondrial disease drug development. We improved a biosensor-based assay of mitochondrial O2 consumption, and identified mitofunctional defects in cell models of LHON and FXTAS. Using this platform, we screened a 1600-compound library of clinically used drugs. The assay identified drugs known to affect mitochondrial function, such as metformin and decoquinate. We also identified several drugs not previously known to affect mitochondrial respiration including acarbose, metaraminol, gallamine triethiodide, and acamprosate. These previously unknown ?mitoactives? represent novel links to targets for mitochondrial regulation and potentially therapy, for mitochondrial disease. Twit Text FOAVip High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects ????Mitochondrion http://www.kidney.de/pget.php?&tw=1&pmid=25034306 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25034306 #FOAvip English Wikipedia <ref>{{Cite pmid|25034306}}</ref> High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects #MMPMID25034306 Sahdeo S; Tomilov A; Komachi K; Iwahashi C; Datta S; Hughes O; Hagerman P; Cortopassi G Mitochondrion 2014[Jul]; 17 (ä): 116-25 PMID25034306show ga Repurposing of FDA-approved drugs with effects on mitochondrial function might shorten the critical path to mitochondrial disease drug development. We improved a biosensor-based assay of mitochondrial O2 consumption, and identified mitofunctional defects in cell models of LHON and FXTAS. Using this platform, we screened a 1600-compound library of clinically used drugs. The assay identified drugs known to affect mitochondrial function, such as metformin and decoquinate. We also identified several drugs not previously known to affect mitochondrial respiration including acarbose, metaraminol, gallamine triethiodide, and acamprosate. These previously unknown ?mitoactives? represent novel links to targets for mitochondrial regulation and potentially therapy, for mitochondrial disease. äHigh-throughput screening of FDA-approved drugs using oxygen biosensor(epmc).pdf DeepDyve Pubget Overpricing