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10.1098/rstb.2013.0516 http://scihub22266oqcxt.onion/10.1098/rstb.2013.0516 C4142037!4142037 !25135977     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25135977 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Philos+Trans+R+Soc+Lond+B+Biol+Sci 2014 ; 369 (1652 ): ? Nephropedia Template TP {{tp|p=25135977 |t=2014. Extracellular vesicles as modulators of cell-to-cell communication in the healthy and diseased brain |pdf=|usr=}}{{25135977 }} gab.com Text Extracellular vesicles as modulators of cell-to-cell communication in the healthy and diseased brain JO: Philos Trans R Soc Lond B Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25135977 #FOAvip Homeostasis relies heavily on effective cell-to-cell communication. In the central nervous system (CNS), probably more so than in other organs, such communication is crucial to support and protect neurons especially during ageing, as well as to control inflammation, remove debris and infectious agents. Emerging evidence indicates that extracellular vesicles (EVs) including endosome-derived exosomes and fragments of the cellular plasma membrane play a key role in intercellular communication by transporting messenger RNA, microRNA (miRNA) and proteins. In neurodegenerative diseases, secreted vesicles not only remove misfolded proteins, but also transfer aggregated proteins and prions and are thus thought to perpetuate diseases by 'infecting' neighbouring cells with these pathogenic proteins. Conversely, in other CNS disorders signals from stressed cells may help control inflammation and inhibit degeneration. EVs may also reflect the status of the CNS and are present in the cerebrospinal fluid indicating that exosomes may act as biomarkers of disease. That extracellular RNA and in particular miRNA, can be transferred by EV also indicates that these vesicles could be used as carriers to specifically target the CNS to deliver immune modulatory drugs, neuroprotective agents and anti-cancer drugs. Here, we discuss the recent evidence indicating the potential role of exosomes in neurological disorders and how knowledge of their biology may enable a Trojan-horse approach to deliver drugs into the CNS and treat neurodegenerative and other disorders of the CNS. Twit Text FOAVip Extracellular vesicles as modulators of cell-to-cell communication in the healthy and diseased brain ????Philos Trans R Soc Lond B Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25135977 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25135977 #FOAvip English Wikipedia <ref>{{Cite pmid|25135977 }}</ref> Extracellular vesicles as modulators of cell-to-cell communication in the healthy and diseased brain #MMPMID25135977 Pegtel DM ; Peferoen L ; Amor S Philos Trans R Soc Lond B Biol Sci 2014[Sep]; 369 (1652 ): ? PMID25135977 show ga Homeostasis relies heavily on effective cell-to-cell communication. In the central nervous system (CNS), probably more so than in other organs, such communication is crucial to support and protect neurons especially during ageing, as well as to control inflammation, remove debris and infectious agents. Emerging evidence indicates that extracellular vesicles (EVs) including endosome-derived exosomes and fragments of the cellular plasma membrane play a key role in intercellular communication by transporting messenger RNA, microRNA (miRNA) and proteins. In neurodegenerative diseases, secreted vesicles not only remove misfolded proteins, but also transfer aggregated proteins and prions and are thus thought to perpetuate diseases by 'infecting' neighbouring cells with these pathogenic proteins. Conversely, in other CNS disorders signals from stressed cells may help control inflammation and inhibit degeneration. EVs may also reflect the status of the CNS and are present in the cerebrospinal fluid indicating that exosomes may act as biomarkers of disease. That extracellular RNA and in particular miRNA, can be transferred by EV also indicates that these vesicles could be used as carriers to specifically target the CNS to deliver immune modulatory drugs, neuroprotective agents and anti-cancer drugs. Here, we discuss the recent evidence indicating the potential role of exosomes in neurological disorders and how knowledge of their biology may enable a Trojan-horse approach to deliver drugs into the CNS and treat neurodegenerative and other disorders of the CNS. |*Models, Neurological [MESH] |Biological Transport/physiology [MESH] |Brain/*physiology/physiopathology [MESH] |Cell Communication/*physiology [MESH] |Drug Delivery Systems/methods [MESH] |Exosomes/*physiology [MESH] |Humans [MESH]Extracellular vesicles as modulators of cell-to-cell communication in (epmc).pdf DeepDyve Pubget Overpricing