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10.1098/rstb.2013.0510 http://scihub22266oqcxt.onion/10.1098/rstb.2013.0510 C4142031!4142031 !25135971     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25135971 &cmd=llinks): Failed to open stream: HTTP request failed! 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Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation |pdf=|usr=}}{{25135971 }} gab.com Text Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation JO: Philos Trans R Soc Lond B Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25135971 #FOAvip Exosomes are small membranous vesicles of endocytic origin that are released by almost every cell type. They exert versatile functions in intercellular communication important for many physiological and pathological processes. Recently, exosomes attracted interest with regard to their role in cell-cell communication in the nervous system. We have shown that exosomes released from oligodendrocytes upon stimulation with the neurotransmitter glutamate are internalized by neurons and enhance the neuronal stress tolerance. Here, we demonstrate that oligodendroglial exosomes also promote neuronal survival during oxygen-glucose deprivation, a model of cerebral ischaemia. We show the transfer from oligodendrocytes to neurons of superoxide dismutase and catalase, enzymes which are known to help cells to resist oxidative stress. Additionally, we identify various effects of oligodendroglial exosomes on neuronal physiology. Electrophysiological analysis using in vitro multi-electrode arrays revealed an increased firing rate of neurons exposed to oligodendroglial exosomes. Moreover, gene expression analysis and phosphorylation arrays uncovered differentially expressed genes and altered signal transduction pathways in neurons after exosome treatment. Our study thus provides new insight into the broad spectrum of action of oligodendroglial exosomes and their effects on neuronal physiology. The exchange of extracellular vesicles between neural cells may exhibit remarkable potential to impact brain performance. Twit Text FOAVip Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation ????Philos Trans R Soc Lond B Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25135971 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25135971 #FOAvip English Wikipedia <ref>{{Cite pmid|25135971 }}</ref> Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation #MMPMID25135971 Fröhlich D ; Kuo WP ; Frühbeis C ; Sun JJ ; Zehendner CM ; Luhmann HJ ; Pinto S ; Toedling J ; Trotter J ; Krämer-Albers EM Philos Trans R Soc Lond B Biol Sci 2014[Sep]; 369 (1652 ): ä PMID25135971 show ga Exosomes are small membranous vesicles of endocytic origin that are released by almost every cell type. They exert versatile functions in intercellular communication important for many physiological and pathological processes. Recently, exosomes attracted interest with regard to their role in cell-cell communication in the nervous system. We have shown that exosomes released from oligodendrocytes upon stimulation with the neurotransmitter glutamate are internalized by neurons and enhance the neuronal stress tolerance. Here, we demonstrate that oligodendroglial exosomes also promote neuronal survival during oxygen-glucose deprivation, a model of cerebral ischaemia. We show the transfer from oligodendrocytes to neurons of superoxide dismutase and catalase, enzymes which are known to help cells to resist oxidative stress. Additionally, we identify various effects of oligodendroglial exosomes on neuronal physiology. Electrophysiological analysis using in vitro multi-electrode arrays revealed an increased firing rate of neurons exposed to oligodendroglial exosomes. Moreover, gene expression analysis and phosphorylation arrays uncovered differentially expressed genes and altered signal transduction pathways in neurons after exosome treatment. Our study thus provides new insight into the broad spectrum of action of oligodendroglial exosomes and their effects on neuronal physiology. The exchange of extracellular vesicles between neural cells may exhibit remarkable potential to impact brain performance. |Action Potentials/physiology [MESH] |Animals [MESH] |Blotting, Western [MESH] |Catalase/metabolism [MESH] |Cell Communication/*physiology [MESH] |Cell Hypoxia/physiology [MESH] |Cells, Cultured [MESH] |Exosomes/*metabolism [MESH] |Gene Expression Regulation/*physiology [MESH] |Glucose/deficiency [MESH] |Immunohistochemistry [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Microarray Analysis [MESH] |Neurons/*physiology [MESH] |Oligodendroglia/metabolism/*physiology [MESH] |Phosphorylation [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Signal Transduction/*physiology [MESH] |Superoxide Dismutase/metabolism [MESH]Multifaceted effects of oligodendroglial exosomes on neurons: impact o(epmc).pdf DeepDyve Pubget Overpricing