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10.1159/000360478 http://scihub22266oqcxt.onion/10.1159/000360478 C4140971!4140971!24713863     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Innate+Immun 2014 ; 6 (5): 639-49 Nephropedia Template TP {{tp|p=24713863|t=2014. Phagocytosis and Killing of Staphylococcus aureus by Human Neutrophils |pdf=|usr=}}{{24713863}} gab.com Text Phagocytosis and Killing of Staphylococcus aureus by Human Neutrophils JO: J Innate Immun http://www.kidney.de/pget.php?&tw=1&pmid=24713863 #FOAvip Neutrophils are essential for host defense against Staphylococcus aureus infections. Although significant progress has been made, our understanding of neutrophil interactions with S. aureus remains incomplete. To provide a more comprehensive view of this process, we investigated phagocytosis and killing of S. aureus by human neutrophils using varied assay conditions in vitro. A greater percentage of bacteria were internalized by adherent neutrophils compared to those in suspension, and, unexpectedly, uptake of S. aureus by adherent neutrophils occurred efficiently in the absence of opsonins. An antibody specific for S. aureus promoted uptake of unopsonized bacteria in suspension, but had little or no capacity to enhance phagocytosis of S. aureus opsonized with normal human serum or by adherent neutrophils. Collectively, these results indicate that assay conditions can have a significant influence on the phagocytosis and killing of S. aureus by neutrophils. More importantly, the results suggest a vaccine approach directed to enhance opsonophagocytosis alone is not sufficient to promote increased killing of S. aureus by human neutrophils. With the emergence and reemergence of antibiotic-resistant microorganisms, establishing parameters that are optimal for studying neutrophil-S. aureus interactions will pave the way towards developing immune-directed strategies for anti-staphylococcal therapies. Twit Text FOAVip Phagocytosis and Killing of Staphylococcus aureus by Human Neutrophils ????J Innate Immun http://www.kidney.de/pget.php?&tw=1&pmid=24713863 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24713863 #FOAvip English Wikipedia <ref>{{Cite pmid|24713863}}</ref> Phagocytosis and Killing of Staphylococcus aureus by Human Neutrophils #MMPMID24713863 Lu T; Porter AR; Kennedy AD; Kobayashi SD; DeLeo FR J Innate Immun 2014[Aug]; 6 (5): 639-49 PMID24713863show ga Neutrophils are essential for host defense against Staphylococcus aureus infections. Although significant progress has been made, our understanding of neutrophil interactions with S. aureus remains incomplete. To provide a more comprehensive view of this process, we investigated phagocytosis and killing of S. aureus by human neutrophils using varied assay conditions in vitro. A greater percentage of bacteria were internalized by adherent neutrophils compared to those in suspension, and, unexpectedly, uptake of S. aureus by adherent neutrophils occurred efficiently in the absence of opsonins. An antibody specific for S. aureus promoted uptake of unopsonized bacteria in suspension, but had little or no capacity to enhance phagocytosis of S. aureus opsonized with normal human serum or by adherent neutrophils. Collectively, these results indicate that assay conditions can have a significant influence on the phagocytosis and killing of S. aureus by neutrophils. More importantly, the results suggest a vaccine approach directed to enhance opsonophagocytosis alone is not sufficient to promote increased killing of S. aureus by human neutrophils. With the emergence and reemergence of antibiotic-resistant microorganisms, establishing parameters that are optimal for studying neutrophil-S. aureus interactions will pave the way towards developing immune-directed strategies for anti-staphylococcal therapies. äPhagocytosis and Killing of Staphylococcus aureus by Human Neutrophils(epmc).pdf DeepDyve Pubget Overpricing