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10.1038/npp.2014.94 http://scihub22266oqcxt.onion/10.1038/npp.2014.94 C4138755!4138755 !24755889     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24755889 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Neuropsychopharmacology 2014 ; 39 (10 ): 2432-40 Nephropedia Template TP {{tp|p=24755889 |t=2014. Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light |pdf=|usr=}}{{24755889 }} gab.com Text Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light JO: Neuropsychopharmacology http://www.kidney.de/pget.php?&tw=1&pmid=24755889 #FOAvip Circadian rhythm and sleep disruptions occur frequently in individuals with alcohol use disorders (AUD) and present significant barriers to treatment. Recently, a variant of adenosine transporter, equilibrative nucleoside transporter 1 (ENT1), was associated with the co-occurrence of sleep problems and AUD. We have previously shown that mice lacking ENT1 (ENT1 KO) have reduced adenosine levels in the striatum and drink more alcohol compared with wild types (WT). However, it is unknown whether ENT1 deletion disrupts circadian rhythms, which may contribute to alcohol preference in ENT1 KO mice. Here we used these mice to determine whether endogenous adenosine regulates circadian genetic and behavioral rhythms and influences alcohol intake during chronodisruption. We examined circadian locomotor activity in ENT1 KO vs WT littermates and found that ENT1 KO mice were both active earlier and hyperactive compared with WT mice at night. We used real-time PCR and immunohistochemistry to estimate striatal clock gene levels and found that PER2 expression in the striatum was blunted by ENT1 deletion or A2A receptor (A2AR) antagonism. Next, we exposed ENT1 KO and WT mice to constant light (LL) and found further elevation in ethanol intake in ENT1 KO, but not in WT mice, supporting the notion that circadian dysfunction may contribute to increased alcohol intake in ENT1 KO mice. Finally, we showed that A2AR agonist administration normalized PER1 and PER2 expression and circadian locomotor activity in ENT1 KO mice. Together, our results demonstrate that adenosine signaling regulates cellular and behavioral circadian timing and influences alcohol intake during chronodisruption. Twit Text FOAVip Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light ????Neuropsychopharmacology http://www.kidney.de/pget.php?&tw=1&pmid=24755889 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24755889 #FOAvip English Wikipedia <ref>{{Cite pmid|24755889 }}</ref> Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light #MMPMID24755889 Ruby CL ; Vadnie CA ; Hinton DJ ; Abulseoud OA ; Walker DL ; O'Connor KM ; Noterman MF ; Choi DS Neuropsychopharmacology 2014[Sep]; 39 (10 ): 2432-40 PMID24755889 show ga Circadian rhythm and sleep disruptions occur frequently in individuals with alcohol use disorders (AUD) and present significant barriers to treatment. Recently, a variant of adenosine transporter, equilibrative nucleoside transporter 1 (ENT1), was associated with the co-occurrence of sleep problems and AUD. We have previously shown that mice lacking ENT1 (ENT1 KO) have reduced adenosine levels in the striatum and drink more alcohol compared with wild types (WT). However, it is unknown whether ENT1 deletion disrupts circadian rhythms, which may contribute to alcohol preference in ENT1 KO mice. Here we used these mice to determine whether endogenous adenosine regulates circadian genetic and behavioral rhythms and influences alcohol intake during chronodisruption. We examined circadian locomotor activity in ENT1 KO vs WT littermates and found that ENT1 KO mice were both active earlier and hyperactive compared with WT mice at night. We used real-time PCR and immunohistochemistry to estimate striatal clock gene levels and found that PER2 expression in the striatum was blunted by ENT1 deletion or A2A receptor (A2AR) antagonism. Next, we exposed ENT1 KO and WT mice to constant light (LL) and found further elevation in ethanol intake in ENT1 KO, but not in WT mice, supporting the notion that circadian dysfunction may contribute to increased alcohol intake in ENT1 KO mice. Finally, we showed that A2AR agonist administration normalized PER1 and PER2 expression and circadian locomotor activity in ENT1 KO mice. Together, our results demonstrate that adenosine signaling regulates cellular and behavioral circadian timing and influences alcohol intake during chronodisruption. |Adenosine A2 Receptor Agonists/pharmacology [MESH] |Adenosine A2 Receptor Antagonists/pharmacology [MESH] |Alcohol Drinking/*physiopathology [MESH] |Animals [MESH] |Central Nervous System Depressants/administration & dosage [MESH] |Circadian Rhythm/drug effects/*physiology [MESH] |Corpus Striatum/drug effects/*physiopathology [MESH] |Equilibrative Nucleoside Transporter 1/genetics/*metabolism [MESH] |Ethanol/administration & dosage [MESH] |Gene Expression [MESH] |Light [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Motor Activity/drug effects/*physiology [MESH] |Period Circadian Proteins/metabolism [MESH] |Photic Stimulation [MESH]Adenosinergic regulation of striatal clock gene expression and ethanol(epmc).pdf DeepDyve Pubget Overpricing