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10.1016/j.resuscitation.2014.05.040 http://scihub22266oqcxt.onion/10.1016/j.resuscitation.2014.05.040 C4138228!4138228!24945902     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Resuscitation 2014 ; 85 (9): 1298-303 Nephropedia Template TP {{tp|p=24945902|t=2014. Hemodynamic Directed CPR Improves Cerebral Perfusion Pressure and Brain Tissue Oxygenation |pdf=|usr=}}{{24945902}} gab.com Text Hemodynamic Directed CPR Improves Cerebral Perfusion Pressure and Brain Tissue Oxygenation JO: Resuscitation http://www.kidney.de/pget.php?&tw=1&pmid=24945902 #FOAvip Aim: Advances in cardiopulmonary resuscitation (CPR) have focused on the generation and maintenance of adequate myocardial blood flow to optimize the return of spontaneous circulation and survival. Much of the morbidity associated with cardiac arrest survivors can be attributed to global brain hypoxic ischemic injury. The objective of this study was to compare cerebral physiological variables using a hemodynamic directed resuscitation strategy versus an absolute depth-guided approach in a porcine model of ventricular fibrillation (VF) cardiac arrest. Methods: Intracranial pressure and brain tissue oxygen tension probes were placed in the frontal cortex prior to induction of VF in 21 female 3month old swine. After 7 minutes of VF, animalswere randomized to receive one of three resuscitation strategies: 1) Hemodynamic Directed Care (CPP-20): chest compressions (CCs) with depth titrated to a target systolic blood pressure of 100 mmHg and titration of vasopressors to maintain coronary perfusion pressure (CPP)> 20 mmHg; 2) Depth 33mm(D33): target CC depth of 33mm with standard American Heart Association (AHA) epinephrine dosing; or 3) Depth 51mm(D51): target CC depth of 51mm with standard AHA epinephrine dosing. Results: Cerebral perfusion pressures (CerePP)were significantly higher in the CPP-20 group compared to both D33 (p<0.01) and D51 (P=0.046), and higher in survivors compared to non-survivors irrespective of treatment group (P<0.01).Brain tissue oxygen tension was also higher in the CPP-20 group compared to both D33 (P<0.01) and D51 (P=0.013), and higher in survivors compared to non-survivors irrespective of treatment group (P<0.01).Subjects with a CPP > 20 mm Hg were 2.7 times more likely to have a CerePP > 30 mm Hg (P< 0.001). Conclusions: Hemodynamic directed resuscitation strategy targeting coronary perfusion pressure > 20 mmHg following VF arrest was associated with higher cerebral perfusion pressures and brain tissue oxygen tensions during CPR. Twit Text FOAVip Hemodynamic Directed CPR Improves Cerebral Perfusion Pressure and Brain Tissue Oxygenation ????Resuscitation http://www.kidney.de/pget.php?&tw=1&pmid=24945902 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24945902 #FOAvip English Wikipedia <ref>{{Cite pmid|24945902}}</ref> Hemodynamic Directed CPR Improves Cerebral Perfusion Pressure and Brain Tissue Oxygenation #MMPMID24945902 Friess SH; Sutton RM; French B; Bhalala U; Maltese MR; Naim MY; Bratinov G; Rodriguez SA; Weiland TR; Garuccio M; Nadkarni VM; Becker LB; Berg RA Resuscitation 2014[Sep]; 85 (9): 1298-303 PMID24945902show ga Aim: Advances in cardiopulmonary resuscitation (CPR) have focused on the generation and maintenance of adequate myocardial blood flow to optimize the return of spontaneous circulation and survival. Much of the morbidity associated with cardiac arrest survivors can be attributed to global brain hypoxic ischemic injury. The objective of this study was to compare cerebral physiological variables using a hemodynamic directed resuscitation strategy versus an absolute depth-guided approach in a porcine model of ventricular fibrillation (VF) cardiac arrest. Methods: Intracranial pressure and brain tissue oxygen tension probes were placed in the frontal cortex prior to induction of VF in 21 female 3month old swine. After 7 minutes of VF, animalswere randomized to receive one of three resuscitation strategies: 1) Hemodynamic Directed Care (CPP-20): chest compressions (CCs) with depth titrated to a target systolic blood pressure of 100 mmHg and titration of vasopressors to maintain coronary perfusion pressure (CPP)> 20 mmHg; 2) Depth 33mm(D33): target CC depth of 33mm with standard American Heart Association (AHA) epinephrine dosing; or 3) Depth 51mm(D51): target CC depth of 51mm with standard AHA epinephrine dosing. Results: Cerebral perfusion pressures (CerePP)were significantly higher in the CPP-20 group compared to both D33 (p<0.01) and D51 (P=0.046), and higher in survivors compared to non-survivors irrespective of treatment group (P<0.01).Brain tissue oxygen tension was also higher in the CPP-20 group compared to both D33 (P<0.01) and D51 (P=0.013), and higher in survivors compared to non-survivors irrespective of treatment group (P<0.01).Subjects with a CPP > 20 mm Hg were 2.7 times more likely to have a CerePP > 30 mm Hg (P< 0.001). Conclusions: Hemodynamic directed resuscitation strategy targeting coronary perfusion pressure > 20 mmHg following VF arrest was associated with higher cerebral perfusion pressures and brain tissue oxygen tensions during CPR. äHemodynamic Directed CPR Improves Cerebral Perfusion Pressure and Brai(epmc).pdf DeepDyve Pubget Overpricing