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10.1016/j.cell.2014.06.027 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.06.027 C4137894!4137894!25083876     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2014 ; 158 (3): 673-88 Nephropedia Template TP {{tp|p=25083876|t=2014. H3K4me3 breadth is linked to cell identity and transcriptional consistency |pdf=|usr=}}{{25083876}} gab.com Text H3K4me3 breadth is linked to cell identity and transcriptional consistency JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=25083876 #FOAvip Trimethylation of Histone H3 at Lysine 4 (H3K4me3) is a chromatin modification known to mark the transcription start sites of active genes. Here we show that H3K4me3 domains that spread more broadly over genes in a given cell type preferentially mark genes essential for the identity and function of that cell type. Using the broadest H3K4me3 domains as a discovery tool in neural progenitor cells, we identify novel regulators of these cells. Machine learning models reveal that the broadest H3K4me3 domains represent a distinct entity, characterized by increased marks of elongation. Broadest H3K4me3 domains also have more paused polymerase at their promoters, suggesting a unique transcriptional output. Indeed, genes marked by broadest H3K4me3 domains exhibit enhanced transcriptional consistency rather than increased transcriptional levels, and perturbation of H3K4me3 breadth leads to changes in transcriptional consistency. Thus, H3K4me3 breadth contains information that could ensure transcriptional precision at key cell identity/function genes. Twit Text FOAVip H3K4me3 breadth is linked to cell identity and transcriptional consistency ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=25083876 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25083876 #FOAvip English Wikipedia <ref>{{Cite pmid|25083876}}</ref> H3K4me3 breadth is linked to cell identity and transcriptional consistency #MMPMID25083876 Benayoun BA; Pollina EA; Uçar D; Mahmoudi S; Karra K; Wong ED; Devarajan K; Daugherty AC; Kundaje AB; Mancini E; Hitz BC; Gupta R; Rando TA; Baker JC; Snyder MP; Cherry JM; Brunet A Cell 2014[Jul]; 158 (3): 673-88 PMID25083876show ga Trimethylation of Histone H3 at Lysine 4 (H3K4me3) is a chromatin modification known to mark the transcription start sites of active genes. Here we show that H3K4me3 domains that spread more broadly over genes in a given cell type preferentially mark genes essential for the identity and function of that cell type. Using the broadest H3K4me3 domains as a discovery tool in neural progenitor cells, we identify novel regulators of these cells. Machine learning models reveal that the broadest H3K4me3 domains represent a distinct entity, characterized by increased marks of elongation. Broadest H3K4me3 domains also have more paused polymerase at their promoters, suggesting a unique transcriptional output. Indeed, genes marked by broadest H3K4me3 domains exhibit enhanced transcriptional consistency rather than increased transcriptional levels, and perturbation of H3K4me3 breadth leads to changes in transcriptional consistency. Thus, H3K4me3 breadth contains information that could ensure transcriptional precision at key cell identity/function genes. äH3K4me3 breadth is linked to cell identity and transcriptional consist(epmc).pdf DeepDyve Pubget Overpricing