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10.1111/cei.12363

http://scihub22266oqcxt.onion/10.1111/cei.12363
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C4137843!4137843!24773566
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suck abstract from ncbi


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pmid24773566      Clin+Exp+Immunol 2014 ; 177 (3): 598-602
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  • ATP4A autoimmunity and Helicobacter pylori infection in children with type 1 diabetes #MMPMID24773566
  • Chobot A; Wenzlau J; Bak-Drabik K; Kwiecien J; Polanska J; Rewers M
  • Clin Exp Immunol 2014[Sep]; 177 (3): 598-602 PMID24773566show ga
  • Persistent presence of ATP4A autoantibodies (ATP4AA) directed towards parietal cells is typical for atrophic body gastritis (ABG), an autoimmune disease associated with type 1 diabetes. We assessed whether Helicobacter pylori (Hp) infection might be associated with positivity for ATP4AA in children with type 1 diabetes. Sera were collected from 70 (38?) type 1 diabetes children [aged 13·2 ± 4·5 years, age at diagnosis 8·8 ± 4·3 years, diabetes duration 4·5 ± 3·8 years, mean HbA1c 7·8 ± 1·6% (62 ± 17·5 mmol/mol)] seen at the regional diabetes clinic in Katowice, Poland. Patients were tested concurrently for Hp infection by means of a 13C urea breath test. ATP4AA were measured using a novel radioimmunoprecipitation assay developed at the Barbara Davies Center for Childhood Diabetes, University of Colorado. ATP4AA were present in 21 [30%, 95% confidence interval (CI) = 19?41%] and Hp infection was detected in 23 (33%, 95% CI = 22?44%) children. There was no statistically significant association between ATP4AA presence and Hp status. ATP4AA presence was not associated with current age, age at type 1 diabetes diagnosis, diabetes duration or current HbA1c. ATP4AA were more prevalent in females [42% (26?58%)] than males [16% (3?28%)], P = 0·016. ATP4A are found in nearly one-third of children with type 1 diabetes and more common among females. In this cross-sectional analysis, Hp infection was not associated with autoimmunity against parietal cells.
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