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10.1097/QCO.0000000000000065 http://scihub22266oqcxt.onion/10.1097/QCO.0000000000000065 C4137468!4137468!24739346     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Infect+Dis 2014 ; 27 (3): 228-35 Nephropedia Template TP {{tp|p=24739346|t=2014. Detecting Specific Infections in Children through Host Responses: A Paradigm Shift |pdf=|usr=}}{{24739346}} gab.com Text Detecting Specific Infections in Children through Host Responses: A Paradigm Shift JO: Curr Opin Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=24739346 #FOAvip Purpose of the review: There is a need for improved diagnosis and for optimal classification of patients with infectious diseases. An alternative approach to the pathogen-detection strategy is based on a comprehensive analysis of the host response to the infection. This review focuses on the value of transcriptome analyses of blood leukocytes for the diagnosis and management of patients with infectious diseases. Recent findings: Initial studies showed that RNA from blood leukocytes of children with acute viral and bacterial infections carried pathogen-specific transcriptional signatures. Subsequently, transcriptional signatures for several other infections have been described and validated in humans with malaria, dengue, salmonella, meloidosis, RSV, influenza, tuberculosis and HIV. In addition, transcriptome analyses represent an invaluable tool to understand disease pathogenesis, and to objectively classify patients according to clinical severity. Summary: Microarray studies have shown to be highly reproducible using different platforms, and in different patient populations, confirming the value of blood transcriptome analyses to study pathogen-specific host immune responses in the clinical setting. Combining the detection of the pathogen with a comprehensive assessment of the host immune response will provide a new understanding of the correlations between specific etiologic agents, the host response and the clinical manifestations of the disease. Twit Text FOAVip Detecting Specific Infections in Children through Host Responses: A Paradigm Shift ????Curr Opin Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=24739346 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24739346 #FOAvip English Wikipedia <ref>{{Cite pmid|24739346}}</ref> Detecting Specific Infections in Children through Host Responses: A Paradigm Shift #MMPMID24739346 Mejias A; Suarez NM; Ramilo O Curr Opin Infect Dis 2014[Jun]; 27 (3): 228-35 PMID24739346show ga Purpose of the review: There is a need for improved diagnosis and for optimal classification of patients with infectious diseases. An alternative approach to the pathogen-detection strategy is based on a comprehensive analysis of the host response to the infection. This review focuses on the value of transcriptome analyses of blood leukocytes for the diagnosis and management of patients with infectious diseases. Recent findings: Initial studies showed that RNA from blood leukocytes of children with acute viral and bacterial infections carried pathogen-specific transcriptional signatures. Subsequently, transcriptional signatures for several other infections have been described and validated in humans with malaria, dengue, salmonella, meloidosis, RSV, influenza, tuberculosis and HIV. In addition, transcriptome analyses represent an invaluable tool to understand disease pathogenesis, and to objectively classify patients according to clinical severity. Summary: Microarray studies have shown to be highly reproducible using different platforms, and in different patient populations, confirming the value of blood transcriptome analyses to study pathogen-specific host immune responses in the clinical setting. Combining the detection of the pathogen with a comprehensive assessment of the host immune response will provide a new understanding of the correlations between specific etiologic agents, the host response and the clinical manifestations of the disease. äDetecting Specific Infections in Children through Host Responses: A Pa(epmc).pdf DeepDyve Pubget Overpricing