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10.1002/eji.201344365 http://scihub22266oqcxt.onion/10.1002/eji.201344365 C4137395!4137395 !24737461     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24737461 &cmd=llinks): Failed to open stream: HTTP request failed! 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Interkeukin-34, a cytokine crucial for the differentiation and maintenance of tissue resident macrophages and Langerhans cells |pdf=|usr=}}{{24737461 }} gab.com Text Interkeukin-34, a cytokine crucial for the differentiation and maintenance of tissue resident macrophages and Langerhans cells JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24737461 #FOAvip IL-34 is a recently discovered cytokine that acts on tissue resident macrophages and Langerhans cells upon binding the receptor for CSF-1, CSF-1R. The existence of two ligands for CSF-1R, IL-34, and CSF-1, raises several intriguing questions. Are IL-34 and CSF-1 redundant or does each perform temporally and spatially distinct functions? Is IL-34 involved in human pathology? Would therapeutic strategies based on selective inhibition or administration of either IL-34 or CSF-1 be advantageous for preventing human pathology? Recent in vivo studies indicate that IL-34 promotes the development, survival, and function of microglia and Langerhans cells; therefore, this cytokine may predominately function in brain and skin biology. Here, we review the evidence for IL-34 as a key cytokine in the development and function of these two diverse cell types and discuss its potential role in pathological conditions. Twit Text FOAVip Interkeukin-34, a cytokine crucial for the differentiation and maintenance of tissue resident macrophages and Langerhans cells ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24737461 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24737461 #FOAvip English Wikipedia <ref>{{Cite pmid|24737461 }}</ref> Interkeukin-34, a cytokine crucial for the differentiation and maintenance of tissue resident macrophages and Langerhans cells #MMPMID24737461 Wang Y ; Colonna M Eur J Immunol 2014[Jun]; 44 (6 ): 1575-81 PMID24737461 show ga IL-34 is a recently discovered cytokine that acts on tissue resident macrophages and Langerhans cells upon binding the receptor for CSF-1, CSF-1R. The existence of two ligands for CSF-1R, IL-34, and CSF-1, raises several intriguing questions. Are IL-34 and CSF-1 redundant or does each perform temporally and spatially distinct functions? Is IL-34 involved in human pathology? Would therapeutic strategies based on selective inhibition or administration of either IL-34 or CSF-1 be advantageous for preventing human pathology? Recent in vivo studies indicate that IL-34 promotes the development, survival, and function of microglia and Langerhans cells; therefore, this cytokine may predominately function in brain and skin biology. Here, we review the evidence for IL-34 as a key cytokine in the development and function of these two diverse cell types and discuss its potential role in pathological conditions. |Animals [MESH] |Cell Differentiation/*immunology [MESH] |Humans [MESH] |Interleukins/*immunology [MESH] |Langerhans Cells/cytology/*immunology [MESH] |Macrophage Colony-Stimulating Factor/immunology [MESH] |Macrophages/cytology/*immunology [MESH] |Microglia/cytology/immunology [MESH]Interkeukin-34, a cytokine crucial for the differentiation and mainten(epmc).pdf DeepDyve Pubget Overpricing