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10.1016/j.cell.2014.03.060 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.03.060 C4136468!4136468!24906150     free     free     free       Cell 2014 ; 157 (6): 1324-38 Nephropedia Template TP {{tp|p=24906150|t=2014. Hippo Pathway Activity Influences Liver Cell Fate |pdf=|usr=}}{{24906150}} gab.com Text Hippo Pathway Activity Influences Liver Cell Fate JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=24906150 #FOAvip The Hippo signaling pathway is an important regulator of cellular proliferation and organ size. However, little is known about the role of this cascade in the control of cell fate. Employing a combination of lineage tracing, clonal analysis, and organoid culture approaches, we demonstrate that Hippo-pathway activity is essential for the maintenance of the differentiated hepatocyte state. Remarkably, acute inactivation of Hippo-pathway signaling in vivo is sufficient to de-differentiate, at very high efficiencies, adult hepatocytes into cells bearing progenitor characteristics. These hepatocyte-derived progenitor cells demonstrate self-renewal and engraftment capacity at the single cell level. We also identify the NOTCH signaling pathway as a functional important effector downstream of the Hippo transducer YAP. Our findings uncover a potent role for Hippo/YAP signaling in controlling liver cell fate, and reveal an unprecedented level of phenotypic plasticity in mature hepatocytes, which has implications for the understanding and manipulation of liver regeneration. Twit Text FOAVip Hippo Pathway Activity Influences Liver Cell Fate ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=24906150 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24906150 #FOAvip English Wikipedia <ref>{{Cite pmid|24906150}}</ref> Hippo Pathway Activity Influences Liver Cell Fate #MMPMID24906150 Yimlamai D; Christodoulou C; Galli GG; Yanger K; Pepe-Mooney B; Gurung B; Shrestha K; Cahan P; Stanger BZ; Camargo FD Cell 2014[Jun]; 157 (6): 1324-38 PMID24906150show ga The Hippo signaling pathway is an important regulator of cellular proliferation and organ size. However, little is known about the role of this cascade in the control of cell fate. Employing a combination of lineage tracing, clonal analysis, and organoid culture approaches, we demonstrate that Hippo-pathway activity is essential for the maintenance of the differentiated hepatocyte state. Remarkably, acute inactivation of Hippo-pathway signaling in vivo is sufficient to de-differentiate, at very high efficiencies, adult hepatocytes into cells bearing progenitor characteristics. These hepatocyte-derived progenitor cells demonstrate self-renewal and engraftment capacity at the single cell level. We also identify the NOTCH signaling pathway as a functional important effector downstream of the Hippo transducer YAP. Our findings uncover a potent role for Hippo/YAP signaling in controlling liver cell fate, and reveal an unprecedented level of phenotypic plasticity in mature hepatocytes, which has implications for the understanding and manipulation of liver regeneration. äHippo Pathway Activity Influences Liver Cell Fate (epmc).pdf DeepDyve Pubget Overpricing