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10.1093/rheumatology/ket414 http://scihub22266oqcxt.onion/10.1093/rheumatology/ket414 C4135582!4135582 !24402580     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24402580 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Rheumatology+(Oxford) 2014 ; 53 (9 ): 1560-9 Nephropedia Template TP {{tp|p=24402580 |t=2014. Rheumatoid arthritis pathophysiology: update on emerging cytokine and cytokine-associated cell targets |pdf=|usr=}}{{24402580 }} gab.com Text Rheumatoid arthritis pathophysiology: update on emerging cytokine and cytokine-associated cell targets JO: Rheumatology (Oxford) http://www.kidney.de/pget.php?&tw=1&pmid=24402580 #FOAvip Biologic therapies that target pathogenic cytokines such as TNF, IL-1? or IL-6 have greatly improved the treatment of RA. Unfortunately, not all RA patients respond to current biologic therapies and responses are not always maintained, suggesting that there are alternative drivers of RA pathogenesis that might serve as promising therapeutic targets. Discovery of the new Th17 subset of Th cells, and their role in autoimmune disease development, has implicated the proinflammatory IL-12 and IL-17 families of cytokines in RA disease pathogenesis. Members of these cytokine families are elevated in the blood and joints of RA patients and have been shown to remain elevated in patients who do not respond to current biologics. In addition, these cytokines have been shown to play roles in joint destruction and erosion. A new subclass of biologics that target the IL-12 and/or IL-17 signalling pathways are under development. Here we review evidence for a role of Th17 cells as well as IL-12 and IL-17 cytokines in RA pathogenesis as the rationale for a subsequent discussion of the ongoing and completed clinical trials of newly emerging biologic therapies directed at IL-12 or IL-17 pathway inhibition. Twit Text FOAVip Rheumatoid arthritis pathophysiology: update on emerging cytokine and cytokine-associated cell targets ????Rheumatology (Oxford) http://www.kidney.de/pget.php?&tw=1&pmid=24402580 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24402580 #FOAvip English Wikipedia <ref>{{Cite pmid|24402580 }}</ref> Rheumatoid arthritis pathophysiology: update on emerging cytokine and cytokine-associated cell targets #MMPMID24402580 Furst DE ; Emery P Rheumatology (Oxford) 2014[Sep]; 53 (9 ): 1560-9 PMID24402580 show ga Biologic therapies that target pathogenic cytokines such as TNF, IL-1? or IL-6 have greatly improved the treatment of RA. Unfortunately, not all RA patients respond to current biologic therapies and responses are not always maintained, suggesting that there are alternative drivers of RA pathogenesis that might serve as promising therapeutic targets. Discovery of the new Th17 subset of Th cells, and their role in autoimmune disease development, has implicated the proinflammatory IL-12 and IL-17 families of cytokines in RA disease pathogenesis. Members of these cytokine families are elevated in the blood and joints of RA patients and have been shown to remain elevated in patients who do not respond to current biologics. In addition, these cytokines have been shown to play roles in joint destruction and erosion. A new subclass of biologics that target the IL-12 and/or IL-17 signalling pathways are under development. Here we review evidence for a role of Th17 cells as well as IL-12 and IL-17 cytokines in RA pathogenesis as the rationale for a subsequent discussion of the ongoing and completed clinical trials of newly emerging biologic therapies directed at IL-12 or IL-17 pathway inhibition. |Antirheumatic Agents/therapeutic use [MESH] |Arthritis, Rheumatoid/drug therapy/*immunology [MESH] |Biological Products/therapeutic use [MESH] |CD4-Positive T-Lymphocytes/immunology [MESH] |Cytokines/antagonists & inhibitors/*immunology [MESH] |Humans [MESH] |Interleukin-12/antagonists & inhibitors/immunology [MESH] |Interleukin-17/antagonists & inhibitors/immunology [MESH] |Molecular Targeted Therapy/*methods/trends [MESH] |T-Lymphocyte Subsets/immunology [MESH]Rheumatoid arthritis pathophysiology: update on emerging cytokine and (epmc).pdf DeepDyve Pubget Overpricing