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10.1016/j.mcn.2014.06.006 http://scihub22266oqcxt.onion/10.1016/j.mcn.2014.06.006 C4135029!4135029!24983518     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell+Neurosci 2014 ; ä (ä): 133-40 Nephropedia Template TP {{tp|p=24983518|t=2014. Autophagy dysregulation in cell culture and animals models of Spinal Muscular Atrophy |pdf=|usr=}}{{24983518}} gab.com Text Autophagy dysregulation in cell culture and animals models of Spinal Muscular Atrophy JO: Mol Cell Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=24983518 #FOAvip Abnormal autophagy has become a central thread linking neurodegenerative diseases, particularly of the motor neuron. One such disease is spinal muscular atrophy (SMA), a genetic neuromuscular disorder caused by mutations in the SMN1 gene resulting in low levels of Survival Motor Neuron (SMN) protein. Despite knowing the causal protein, the exact intracellular processes that are involved in the selective loss of motor neurons remains unclear. Autophagy induction can be helpful or harmful depending on the situation, and we sought to understand the state of the autophagic response in SMA. We show that cell culture and animal models demonstrate induction of autophagy accompanied by attenuated autophagic flux, resulting in the accumulation of autophagosomes and their associated cargo. Expression of the SMN-binding protein a-COP, a known modulator of autophagic flux, can ameliorate this autophagic traffic jam. Twit Text FOAVip Autophagy dysregulation in cell culture and animals models of Spinal Muscular Atrophy ????Mol Cell Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=24983518 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24983518 #FOAvip English Wikipedia <ref>{{Cite pmid|24983518}}</ref> Autophagy dysregulation in cell culture and animals models of Spinal Muscular Atrophy #MMPMID24983518 Custer SK; Androphy EJ Mol Cell Neurosci 2014[Jul]; ä (ä): 133-40 PMID24983518show ga Abnormal autophagy has become a central thread linking neurodegenerative diseases, particularly of the motor neuron. One such disease is spinal muscular atrophy (SMA), a genetic neuromuscular disorder caused by mutations in the SMN1 gene resulting in low levels of Survival Motor Neuron (SMN) protein. Despite knowing the causal protein, the exact intracellular processes that are involved in the selective loss of motor neurons remains unclear. Autophagy induction can be helpful or harmful depending on the situation, and we sought to understand the state of the autophagic response in SMA. We show that cell culture and animal models demonstrate induction of autophagy accompanied by attenuated autophagic flux, resulting in the accumulation of autophagosomes and their associated cargo. Expression of the SMN-binding protein a-COP, a known modulator of autophagic flux, can ameliorate this autophagic traffic jam. äAutophagy dysregulation in cell culture and animals models of Spinal M(epmc).pdf DeepDyve Pubget Overpricing