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10.1016/j.cellsig.2014.05.011 http://scihub22266oqcxt.onion/10.1016/j.cellsig.2014.05.011 C4134338!4134338!24863881     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Signal 2014 ; 26 (9): 1950-7 Nephropedia Template TP {{tp|p=24863881|t=2014. Recent Progress in the Study of the Rheb family GTPases |pdf=|usr=}}{{24863881}} gab.com Text Recent Progress in the Study of the Rheb family GTPases JO: Cell Signal http://www.kidney.de/pget.php?&tw=1&pmid=24863881 #FOAvip In this review we highlight recent progress in the study of Rheb family GTPases. Structural studies using X-ray crystallography and NMR have given us insight into unique features of this GTPase. Combined with mutagenesis studies, these works have expanded our understanding of residues that affect Rheb GTP/GDP bound ratios, effector protein interactions, and stimulation of mTORC1 signaling. Analysis of cancer genome databases has revealed that several human carcinomas contain activating mutations of the protein. Rheb?s role in activating mTORC1 signaling at the lysosome in response to stimuli has been further elucidated. Rheb has also been suggested to play roles in other cellular pathways including mitophagy and peroxisomal ROS response. A number of studies in mice have demonstrated the importance of Rheb in development, as well as in a variety of functions including cardiac protection and myelination. We conclude with a discussion of future prospects in the study of Rheb family GTPases. Twit Text FOAVip Recent Progress in the Study of the Rheb family GTPases ????Cell Signal http://www.kidney.de/pget.php?&tw=1&pmid=24863881 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24863881 #FOAvip English Wikipedia <ref>{{Cite pmid|24863881}}</ref> Recent Progress in the Study of the Rheb family GTPases #MMPMID24863881 Heard JJ; Fong V; Bathaie SZ; Tamanoi F Cell Signal 2014[Sep]; 26 (9): 1950-7 PMID24863881show ga In this review we highlight recent progress in the study of Rheb family GTPases. Structural studies using X-ray crystallography and NMR have given us insight into unique features of this GTPase. Combined with mutagenesis studies, these works have expanded our understanding of residues that affect Rheb GTP/GDP bound ratios, effector protein interactions, and stimulation of mTORC1 signaling. Analysis of cancer genome databases has revealed that several human carcinomas contain activating mutations of the protein. Rheb?s role in activating mTORC1 signaling at the lysosome in response to stimuli has been further elucidated. Rheb has also been suggested to play roles in other cellular pathways including mitophagy and peroxisomal ROS response. A number of studies in mice have demonstrated the importance of Rheb in development, as well as in a variety of functions including cardiac protection and myelination. We conclude with a discussion of future prospects in the study of Rheb family GTPases. äRecent Progress in the Study of the Rheb family GTPases (epmc).pdf DeepDyve Pubget Overpricing