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10.1021/nl502338y

http://scihub22266oqcxt.onion/10.1021/nl502338y
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C4134139!4134139!25029087
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suck abstract from ncbi


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pmid25029087      Nano+Lett 2014 ; 14 (8): 4887-94
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  • Spatiotemporal Intracellular Nitric Oxide Signaling Captured Using Internalized, Near-Infrared Fluorescent Carbon Nanotube Nanosensors #MMPMID25029087
  • Ulissi Z; Sen F; Gong X; Sen S; Iverson N; Boghossian A; Godoy LC; Wogan GN; Mukhopadhyay D; Strano MS
  • Nano Lett 2014[Aug]; 14 (8): 4887-94 PMID25029087show ga
  • Fluorescent nanosensor probes have suffered from limited molecular recognition and a dearth of strategies for spatial-temporal operation in cell culture. In this work, we spatially imaged the dynamics of nitric oxide (NO) signaling, important in numerous pathologies and physiological functions, using intracellular near-infrared fluorescent single-walled carbon nanotubes. The observed spatial-temporal NO signaling gradients clarify and refine the existing paradigm of NO signaling based on averaged local concentrations. This work enables the study of transient intracellular phenomena associated with signaling and therapeutics.
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