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10.1002/psc.2657 http://scihub22266oqcxt.onion/10.1002/psc.2657 C4133282!4133282!24909552     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Pept+Sci 2014 ; 20 (9): 704-15 Nephropedia Template TP {{tp|p=24909552|t=2014. Captides: Rigid Junctions between Beta Sheets and Small Molecules |pdf=|usr=}}{{24909552}} gab.com Text Captides: Rigid Junctions between Beta Sheets and Small Molecules JO: J Pept Sci http://www.kidney.de/pget.php?&tw=1&pmid=24909552 #FOAvip An extensive series of covalently linked small molecule-peptide adducts based on a terminally capped beta hairpin motif is reported. The constructs can be prepared by standard solid-phase fmoc chemistry with 1 to 4 peptide chains linked to small molecule hubs bearing carboxylic acid moieties. The key feature of interest is the precise, buried environment of the small molecule, and its rigid orientation relative to one or more short, but fully structured peptide chain(s). Most of this study employs a minimalist 9 residue ?captide?, a capped ?-turn, but we illustrate general applicability to peptides which can terminate in a beta strand. The non-peptide portion of these adducts can include nearly any molecule bearing one or more carboxylic acid groups. Fold-dependent rigidity sets this strategy apart from currently available bioconjugation methods, which typically engender significant flexibility between peptide and tag. Applications to catalyst enhancement, drug design, higher-order assembly, and FRET calibration rulers are discussed. Twit Text FOAVip Captides: Rigid Junctions between Beta Sheets and Small Molecules ????J Pept Sci http://www.kidney.de/pget.php?&tw=1&pmid=24909552 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24909552 #FOAvip English Wikipedia <ref>{{Cite pmid|24909552}}</ref> Captides: Rigid Junctions between Beta Sheets and Small Molecules #MMPMID24909552 Kier BL; Andersen NH J Pept Sci 2014[Sep]; 20 (9): 704-15 PMID24909552show ga An extensive series of covalently linked small molecule-peptide adducts based on a terminally capped beta hairpin motif is reported. The constructs can be prepared by standard solid-phase fmoc chemistry with 1 to 4 peptide chains linked to small molecule hubs bearing carboxylic acid moieties. The key feature of interest is the precise, buried environment of the small molecule, and its rigid orientation relative to one or more short, but fully structured peptide chain(s). Most of this study employs a minimalist 9 residue ?captide?, a capped ?-turn, but we illustrate general applicability to peptides which can terminate in a beta strand. The non-peptide portion of these adducts can include nearly any molecule bearing one or more carboxylic acid groups. Fold-dependent rigidity sets this strategy apart from currently available bioconjugation methods, which typically engender significant flexibility between peptide and tag. Applications to catalyst enhancement, drug design, higher-order assembly, and FRET calibration rulers are discussed. äCaptides: Rigid Junctions between Beta Sheets and Small Molecules (epmc).pdf DeepDyve Pubget Overpricing