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10.1097/WCO.0000000000000094

http://scihub22266oqcxt.onion/10.1097/WCO.0000000000000094
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C4132635!4132635!24722325
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suck abstract from ncbi


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pmid24722325      Curr+Opin+Neurol 2014 ; 27 (3): 271-8
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  • Relapsing and progressive forms of multiple sclerosis ? insights from pathology #MMPMID24722325
  • Dutta R; Trapp BD
  • Curr Opin Neurol 2014[Jun]; 27 (3): 271-8 PMID24722325show ga
  • PURPOSE OF THIS REVIEW: The predominant clinical disease course of multiple sclerosis (MS) starts with reversible episodes of neurological disability, which transforms into progressive neurological decline. This review provides insight into the pathological differences during relapsing and progressive phases of MS. RECENT FINDINGS: The clinical course of MS is variable and the disease can be classified into relapsing and progressive phases. Pathological studies have been successful in distinguishing between these two forms of the disease and correlate with the clinical findings in terms of cellular responses, the inflammatory environment, and the location of lesions. SUMMARY: Available therapies for MS patients, while effective during the relapsing phase, have little benefit for progressive MS patients. Development of therapies to benefit progressive MS patients will require a better understanding of the pathogenesis of progressive MS. This review discusses and compares the pathological findings in relapsing and progressive MS patients.
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