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2014 ; 157
(6
): 1279-1291
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
Meteorin-like is a hormone that regulates immune-adipose interactions to increase
beige fat thermogenesis
#MMPMID24906147
Rao RR
; Long JZ
; White JP
; Svensson KJ
; Lou J
; Lokurkar I
; Jedrychowski MP
; Ruas JL
; Wrann CD
; Lo JC
; Camera DM
; Lachey J
; Gygi S
; Seehra J
; Hawley JA
; Spiegelman BM
Cell
2014[Jun]; 157
(6
): 1279-1291
PMID24906147
show ga
Exercise training benefits many organ systems and offers protection against
metabolic disorders such as obesity and diabetes. Using the recently identified
isoform of PGC1-? (PGC1-?4) as a discovery tool, we report the identification of
meteorin-like (Metrnl), a circulating factor that is induced in muscle after
exercise and in adipose tissue upon cold exposure. Increasing circulating levels
of Metrnl stimulates energy expenditure and improves glucose tolerance and the
expression of genes associated with beige fat thermogenesis and anti-inflammatory
cytokines. Metrnl stimulates an eosinophil-dependent increase in IL-4 expression
and promotes alternative activation of adipose tissue macrophages, which are
required for the increased expression of the thermogenic and anti-inflammatory
gene programs in fat. Importantly, blocking Metrnl actions in vivo significantly
attenuates chronic cold-exposure-induced alternative macrophage activation and
thermogenic gene responses. Thus, Metrnl links host-adaptive responses to the
regulation of energy homeostasis and tissue inflammation and has therapeutic
potential for metabolic and inflammatory diseases.