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10.1016/j.cellsig.2014.04.022

http://scihub22266oqcxt.onion/10.1016/j.cellsig.2014.04.022
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suck abstract from ncbi


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pmid24793301
      Cell+Signal 2014 ; 26 (10 ): 2284-97
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  • Progress toward advanced understanding of metabotropic glutamate receptors: structure, signaling and therapeutic indications #MMPMID24793301
  • Yin S ; Niswender CM
  • Cell Signal 2014[Oct]; 26 (10 ): 2284-97 PMID24793301 show ga
  • The metabotropic glutamate (mGlu) receptors are a group of Class C seven-transmembrane spanning/G protein-coupled receptors (7TMRs/GPCRs). These receptors are activated by glutamate, one of the standard amino acids and the major excitatory neurotransmitter. By activating G protein-dependent and non-G protein-dependent signaling pathways, mGlus modulate glutamatergic transmission both in the periphery and throughout the central nervous system. Since the discovery of the first mGlu receptor, and especially during the last decade, a great deal of progress has been made in understanding the signaling, structure, pharmacological manipulation and therapeutic indications of the 8 mGlu members.
  • |Allosteric Regulation [MESH]
  • |Antipsychotic Agents/therapeutic use [MESH]
  • |Central Nervous System Diseases/drug therapy/metabolism [MESH]
  • |Humans [MESH]
  • |Ligands [MESH]
  • |Receptors, G-Protein-Coupled/metabolism [MESH]
  • |Receptors, Metabotropic Glutamate/agonists/*metabolism [MESH]


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