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2014 ; 26
(10
): 2284-97
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Progress toward advanced understanding of metabotropic glutamate receptors:
structure, signaling and therapeutic indications
#MMPMID24793301
Yin S
; Niswender CM
Cell Signal
2014[Oct]; 26
(10
): 2284-97
PMID24793301
show ga
The metabotropic glutamate (mGlu) receptors are a group of Class C
seven-transmembrane spanning/G protein-coupled receptors (7TMRs/GPCRs). These
receptors are activated by glutamate, one of the standard amino acids and the
major excitatory neurotransmitter. By activating G protein-dependent and non-G
protein-dependent signaling pathways, mGlus modulate glutamatergic transmission
both in the periphery and throughout the central nervous system. Since the
discovery of the first mGlu receptor, and especially during the last decade, a
great deal of progress has been made in understanding the signaling, structure,
pharmacological manipulation and therapeutic indications of the 8 mGlu members.
|Allosteric Regulation
[MESH]
|Antipsychotic Agents/therapeutic use
[MESH]
|Central Nervous System Diseases/drug therapy/metabolism
[MESH]