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10.4161/cbt.29854 http://scihub22266oqcxt.onion/10.4161/cbt.29854 C4130731!4130731!25117082     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25117082&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Biol+Ther 2014 ; 15 (10): 1378-94 Nephropedia Template TP {{tp|p=25117082|t=2014. Identification of cancer stem cells and a strategy for their elimination |pdf=|usr=}}{{25117082}} gab.com Text Identification of cancer stem cells and a strategy for their elimination JO: Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=25117082 #FOAvip It has been established previously that up to 40% of mouse CD34+ hematopoietic stem cells are capable of internalizing exogenous dsDNA fragments both in vivo and ex vivo. Importantly, when mice are treated with a combination of cyclophosphamide and dsDNA, the repair of interstrand crosslinks in hematopoietic progenitors is attenuated, and their pluripotency is altered. Here we show for the first time that among various actively proliferating mammalian cell populations there are subpopulations capable of internalizing dsDNA fragments. In the context of cancer, such dsDNA-internalizing cell subpopulations display cancer stem cell-like phenotype. Furthermore, using Krebs-2 ascites cells as a model, we found that upon combined treatment with cyclophosphamide and dsDNA, engrafted material loses its tumor-initiating properties which we attribute to the elimination of tumor-initiating stem cell subpopulation or loss of its tumorigenic potential. Twit Text FOAVip Identification of cancer stem cells and a strategy for their elimination ????Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=25117082 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25117082 #FOAvip English Wikipedia <ref>{{Cite pmid|25117082}}</ref> Identification of cancer stem cells and a strategy for their elimination #MMPMID25117082 Dolgova EV; Alyamkina EA; Efremov YR; Nikolin VP; Popova NA; Tyrinova TV; Kozel AV; Minkevich AM; Andrushkevich OM; Zavyalov EL; Romaschenko AV; Bayborodin SI; Taranov OS; Omigov VV; Shevela EY; Stupak VV; Mishinov SV; Rogachev VA; Proskurina AS; Mayorov VI; Shurdov MA; Ostanin AA; Chernykh ER; Bogachev SS Cancer Biol Ther 2014[Oct]; 15 (10): 1378-94 PMID25117082show ga It has been established previously that up to 40% of mouse CD34+ hematopoietic stem cells are capable of internalizing exogenous dsDNA fragments both in vivo and ex vivo. Importantly, when mice are treated with a combination of cyclophosphamide and dsDNA, the repair of interstrand crosslinks in hematopoietic progenitors is attenuated, and their pluripotency is altered. Here we show for the first time that among various actively proliferating mammalian cell populations there are subpopulations capable of internalizing dsDNA fragments. In the context of cancer, such dsDNA-internalizing cell subpopulations display cancer stem cell-like phenotype. Furthermore, using Krebs-2 ascites cells as a model, we found that upon combined treatment with cyclophosphamide and dsDNA, engrafted material loses its tumor-initiating properties which we attribute to the elimination of tumor-initiating stem cell subpopulation or loss of its tumorigenic potential. äIdentification of cancer stem cells and a strategy for their eliminati(epmc).pdf DeepDyve Pubget Overpricing