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10.4161/cbt.29928

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suck abstract from ncbi


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pmid25046606
      Cancer+Biol+Ther 2014 ; 15 (10 ): 1299-300
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  • Ipilimumab: a potential immunologic agent in the treatment of metastatic castration-resistant prostate cancer #MMPMID25046606
  • Kittai A ; Meshikhes M ; Aragon-Ching JB
  • Cancer Biol Ther 2014[Oct]; 15 (10 ): 1299-300 PMID25046606 show ga
  • Immunotherapy has garnered an important place in the therapeutic landscape of treatment in prostate cancer since approval of sipuleucel-T. Ipilimumab is a checkpoint inhibitor that is currently approved for the treatment of advanced melanoma. In the June issue of Lancet Oncology, Kwon and colleagues report the phase III trial using ipilimumab in a post-docetaxel metastatic castration-resistant prostate cancer population. While the primary endpoint of overall survival was not met, several lessons are learned from the analysis of this trial. Perhaps better refinement of a more favorable group of patients who may potentially benefit from an immunologic treatment should be advocated.
  • |*Immunotherapy [MESH]
  • |Cancer Vaccines/*therapeutic use [MESH]
  • |Humans [MESH]
  • |Intercellular Adhesion Molecule-1/*therapeutic use [MESH]
  • |Male [MESH]
  • |Prostatic Neoplasms/*therapy [MESH]


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