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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Gen+Comp+Endocrinol 2014 ; ä (ä): 146-57 Nephropedia Template TP
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Comparative endocrinology of leptin: Assessing function in a phylogenetic context #MMPMID24525452
Londraville RL; Macotela Y; Duff RJ; Easterling MR; Liu Q; Crespi EJ
Gen Comp Endocrinol 2014[Jul]; ä (ä): 146-57 PMID24525452show ga
As we approach the end of two decades of leptin research, the comparative biology of leptin is just beginning. We now have several leptin orthologs described from nearly every major clade among vertebrates, and are moving beyond gene descriptions to functional studies. Even at this early stage, it is clear that non-mammals display clear functional similarities and differences with their better-studied mammalian counterparts. This review assesses what we know about leptin function in mammals and non-mammals, and gives examples of how these data can inform leptin biology in humans.