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10.4161/cbt.29691 http://scihub22266oqcxt.onion/10.4161/cbt.29691 C4128869!4128869 !24971465     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24971465 &cmd=llinks): Failed to open stream: HTTP request failed! 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Chk1-induced CCNB1 overexpression promotes cell proliferation and tumor growth in human colorectal cancer |pdf=|usr=}}{{24971465 }} gab.com Text Chk1-induced CCNB1 overexpression promotes cell proliferation and tumor growth in human colorectal cancer JO: Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=24971465 #FOAvip The high morbidity and mortality of colorectal cancer pose a significant public health problem worldwide. Here we assessed the pro-cancer efficacy and mechanism of action of CCNB1 in different colorectal cancer cells. We provided evidence that CCNB1 mRNA and protein level were upregulated in a subset of human colorectal tumors, and positively correlated with Chk1 expression. Repression of Chk1 caused a significant decrease in cell proliferation and CCNB1 protein expression in colorectal cancer cells. Furthermore, downregulation of CCNB1 impaired colorectal cancer proliferation in vitro and tumor growth in vivo. Specifically, suppression of CCNB1 caused a strong G 2/M phase arrest in both HCT116 and SW480 cells, interfering with the expression of cdc25c and CDK1. Additionally, CCNB1 inhibition induced apoptotic death in certain colorectal cancer cells. Together, these results suggest that CCNB1 is activated by Chk1, exerts its oncogenic role in colorectal cancer cells, and may play a key role in the development of a novel therapeutic approach against colorectal cancer. Twit Text FOAVip Chk1-induced CCNB1 overexpression promotes cell proliferation and tumor growth in human colorectal cancer ????Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=24971465 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24971465 #FOAvip English Wikipedia <ref>{{Cite pmid|24971465 }}</ref> Chk1-induced CCNB1 overexpression promotes cell proliferation and tumor growth in human colorectal cancer #MMPMID24971465 Fang Y ; Yu H ; Liang X ; Xu J ; Cai X Cancer Biol Ther 2014[Sep]; 15 (9 ): 1268-79 PMID24971465 show ga The high morbidity and mortality of colorectal cancer pose a significant public health problem worldwide. Here we assessed the pro-cancer efficacy and mechanism of action of CCNB1 in different colorectal cancer cells. We provided evidence that CCNB1 mRNA and protein level were upregulated in a subset of human colorectal tumors, and positively correlated with Chk1 expression. Repression of Chk1 caused a significant decrease in cell proliferation and CCNB1 protein expression in colorectal cancer cells. Furthermore, downregulation of CCNB1 impaired colorectal cancer proliferation in vitro and tumor growth in vivo. Specifically, suppression of CCNB1 caused a strong G 2/M phase arrest in both HCT116 and SW480 cells, interfering with the expression of cdc25c and CDK1. Additionally, CCNB1 inhibition induced apoptotic death in certain colorectal cancer cells. Together, these results suggest that CCNB1 is activated by Chk1, exerts its oncogenic role in colorectal cancer cells, and may play a key role in the development of a novel therapeutic approach against colorectal cancer. |Animals [MESH] |Apoptosis [MESH] |Apoptosis Regulatory Proteins/metabolism [MESH] |CDC2 Protein Kinase [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation [MESH] |Checkpoint Kinase 1 [MESH] |Colorectal Neoplasms/*metabolism/pathology [MESH] |Cyclin B1/genetics/*metabolism [MESH] |Cyclin-Dependent Kinases/metabolism [MESH] |Down-Regulation [MESH] |G2 Phase Cell Cycle Checkpoints [MESH] |Gene Knockdown Techniques [MESH] |Heterografts [MESH] |Humans [MESH] |M Phase Cell Cycle Checkpoints [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Protein Kinases/genetics/*metabolism [MESH]Chk1-induced CCNB1 overexpression promotes cell proliferation and tumo(epmc).pdf DeepDyve Pubget Overpricing