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10.4161/cbt.29686 http://scihub22266oqcxt.onion/10.4161/cbt.29686 C4128865!4128865 !24971746     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24971746 &cmd=llinks): Failed to open stream: HTTP request failed! 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Genetically engineered Newcastle disease virus expressing interleukin-2 and TNF-related apoptosis-inducing ligand for cancer therapy |pdf=|usr=}}{{24971746 }} gab.com Text Genetically engineered Newcastle disease virus expressing interleukin-2 and TNF-related apoptosis-inducing ligand for cancer therapy JO: Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=24971746 #FOAvip Recombinant Newcastle disease virus (rNDV) have shown oncolytic therapeutic efficacy in preclinical studies and are currently in clinical trials. In this study, we have evaluated the possibility to enhance the cancer therapeutic potential of NDV by means of inserting both interleukin-2 (IL-2) and tumor necrosis factor-related apoptosis inducing ligand (TRAIL) delivered by rNDV. We demonstrated that rNDV expressing TRAIL (rNDV-TRAIL) or both human IL-2 and TRAIL (rNDV-IL-2-TRAIL) significantly enhanced inherent anti-neoplastic of rNDV by inducing apoptosis. And we showed that apoptosis-related genes mRNA expression was increased after treated with rNDV-TRAIL or rNDV-IL-2-TRAIL compared with rNDV and rNDV-IL-2. We also demonstrated that both rNDV-IL-2 and rNDV-IL-2-TRAIL induced proliferation of the CD4(+) and CD8(+) in treated mice and elicited expression of TNF-? and IFN-? antitumor cytokines. These mice treated with oncolytic agents exhibited significant reduction in tumor development compared with mice treated with the parental virus. In addition, experiments in both hepatocellular carcinoma and melanoma-bearing mice demonstrated that the genetically engineered rNDV-IL-2-TRAIL exhibited prolonged animals' survival compared with rNDV, rNDV-IL-2, and rNDV-TRAIL. In conclusion, the immunotherapy and oncolytic virotherapy properties of NDV can be enhanced by the introduction of IL-2 and TRAIL genes, whose products initiated a broad cascade of immunological affects and induced tumor cells apoptosis in the microenvironment of the immune system. Twit Text FOAVip Genetically engineered Newcastle disease virus expressing interleukin-2 and TNF-related apoptosis-inducing ligand for cancer therapy ????Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=24971746 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24971746 #FOAvip English Wikipedia <ref>{{Cite pmid|24971746 }}</ref> Genetically engineered Newcastle disease virus expressing interleukin-2 and TNF-related apoptosis-inducing ligand for cancer therapy #MMPMID24971746 Bai FL ; Yu YH ; Tian H ; Ren GP ; Wang H ; Zhou B ; Han XH ; Yu QZ ; Li DS Cancer Biol Ther 2014[Sep]; 15 (9 ): 1226-38 PMID24971746 show ga Recombinant Newcastle disease virus (rNDV) have shown oncolytic therapeutic efficacy in preclinical studies and are currently in clinical trials. In this study, we have evaluated the possibility to enhance the cancer therapeutic potential of NDV by means of inserting both interleukin-2 (IL-2) and tumor necrosis factor-related apoptosis inducing ligand (TRAIL) delivered by rNDV. We demonstrated that rNDV expressing TRAIL (rNDV-TRAIL) or both human IL-2 and TRAIL (rNDV-IL-2-TRAIL) significantly enhanced inherent anti-neoplastic of rNDV by inducing apoptosis. And we showed that apoptosis-related genes mRNA expression was increased after treated with rNDV-TRAIL or rNDV-IL-2-TRAIL compared with rNDV and rNDV-IL-2. We also demonstrated that both rNDV-IL-2 and rNDV-IL-2-TRAIL induced proliferation of the CD4(+) and CD8(+) in treated mice and elicited expression of TNF-? and IFN-? antitumor cytokines. These mice treated with oncolytic agents exhibited significant reduction in tumor development compared with mice treated with the parental virus. In addition, experiments in both hepatocellular carcinoma and melanoma-bearing mice demonstrated that the genetically engineered rNDV-IL-2-TRAIL exhibited prolonged animals' survival compared with rNDV, rNDV-IL-2, and rNDV-TRAIL. In conclusion, the immunotherapy and oncolytic virotherapy properties of NDV can be enhanced by the introduction of IL-2 and TRAIL genes, whose products initiated a broad cascade of immunological affects and induced tumor cells apoptosis in the microenvironment of the immune system. |Animals [MESH] |Apoptosis [MESH] |Apoptosis Regulatory Proteins/metabolism [MESH] |CD4 Lymphocyte Count [MESH] |CD4-Positive T-Lymphocytes/metabolism [MESH] |CD8-Positive T-Lymphocytes/metabolism [MESH] |Carcinoma, Hepatocellular/immunology/*therapy [MESH] |Cell Line [MESH] |Cell Proliferation [MESH] |Chick Embryo [MESH] |Female [MESH] |Genetic Engineering [MESH] |Humans [MESH] |Interferon-gamma/metabolism [MESH] |Interleukin-2/genetics/*metabolism [MESH] |Liver Neoplasms/immunology/*therapy [MESH] |Melanoma/immunology/*therapy [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C57BL [MESH] |Newcastle disease virus/*genetics/metabolism [MESH] |Oncolytic Virotherapy [MESH] |Oncolytic Viruses/*genetics/metabolism [MESH] |TNF-Related Apoptosis-Inducing Ligand/genetics/*metabolism [MESH]Genetically engineered Newcastle disease virus expressing interleukin-(epmc).pdf DeepDyve Pubget Overpricing