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10.4161/cbt.29500 http://scihub22266oqcxt.onion/10.4161/cbt.29500 C4128862!4128862 !24919179     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24919179 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Biol+Ther 2014 ; 15 (9 ): 1198-207 Nephropedia Template TP {{tp|p=24919179 |t=2014. The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer |pdf=|usr=}}{{24919179 }} gab.com Text The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer JO: Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=24919179 #FOAvip HPP1 (hyperplastic polyposis protein 1), a tumor suppressor gene, is downregulated by promoter hypermethylation in a number of tumor types including colon cancer. c-Myc is also known to play a role in the suppression of HPP1 expression via binding to a promoter region cognate E-box site. The contribution of histone deacetylation as an additional epigenetic mechanism and its potential interplay with c-Myc in the transcriptional regulation of HPP1 are unknown. We have shown that the treatment of the HPP1-non-expressing colon cancer cell lines, HCT116 and DLD-1 with HDAC inhibitors results in re-expression of HPP1. RNAi-mediated knockdown of c-Myc as well as of HDAC2 and HDAC3 in HCT116 and of HDAC1 and HDAC3 in DLD-1 also resulted in significant re-expression of HPP1. Co-immunoprecipitation (IP), chromatin IP (ChIP), and sequential ChIP experiments demonstrated binding of c-Myc to the HPP1 promoter with recruitment of and direct interaction with HDAC3. In summary, we have demonstrated that c-Myc contributes to the epigenetic regulation of HPP1 via the dominant recruitment of HDAC3. Our findings may lead to a greater biologic understanding for the application of targeted use of HDAC inhibitors for anti-cancer therapy. Twit Text FOAVip The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer ????Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=24919179 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24919179 #FOAvip English Wikipedia <ref>{{Cite pmid|24919179 }}</ref> The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer #MMPMID24919179 Wang J ; Elahi A ; Ajidahun A ; Clark W ; Hernandez J ; Achille A ; Hao JH ; Seto E ; Shibata D Cancer Biol Ther 2014[Sep]; 15 (9 ): 1198-207 PMID24919179 show ga HPP1 (hyperplastic polyposis protein 1), a tumor suppressor gene, is downregulated by promoter hypermethylation in a number of tumor types including colon cancer. c-Myc is also known to play a role in the suppression of HPP1 expression via binding to a promoter region cognate E-box site. The contribution of histone deacetylation as an additional epigenetic mechanism and its potential interplay with c-Myc in the transcriptional regulation of HPP1 are unknown. We have shown that the treatment of the HPP1-non-expressing colon cancer cell lines, HCT116 and DLD-1 with HDAC inhibitors results in re-expression of HPP1. RNAi-mediated knockdown of c-Myc as well as of HDAC2 and HDAC3 in HCT116 and of HDAC1 and HDAC3 in DLD-1 also resulted in significant re-expression of HPP1. Co-immunoprecipitation (IP), chromatin IP (ChIP), and sequential ChIP experiments demonstrated binding of c-Myc to the HPP1 promoter with recruitment of and direct interaction with HDAC3. In summary, we have demonstrated that c-Myc contributes to the epigenetic regulation of HPP1 via the dominant recruitment of HDAC3. Our findings may lead to a greater biologic understanding for the application of targeted use of HDAC inhibitors for anti-cancer therapy. |Acetylation [MESH] |Cell Line, Tumor [MESH] |Colonic Neoplasms/genetics/*metabolism/pathology [MESH] |Down-Regulation [MESH] |Epigenesis, Genetic [MESH] |Gene Knockdown Techniques [MESH] |Histone Deacetylase Inhibitors/pharmacology [MESH] |Histone Deacetylases/genetics/*metabolism [MESH] |Histones/metabolism [MESH] |Humans [MESH] |Membrane Proteins/genetics/*metabolism [MESH] |Neoplasm Proteins/genetics/*metabolism [MESH] |Promoter Regions, Genetic [MESH] |Proto-Oncogene Proteins c-myc/genetics/*metabolism [MESH] |RNA, Small Interfering/genetics [MESH]The interplay between histone deacetylases and c-Myc in the transcript(epmc).pdf DeepDyve Pubget Overpricing