Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.4161/cbt.29502 http://scihub22266oqcxt.onion/10.4161/cbt.29502 C4128860!4128860 !24918581     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24918581 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Biol+Ther 2014 ; 15 (9 ): 1174-84 Nephropedia Template TP {{tp|p=24918581 |t=2014. QKI impairs self-renewal and tumorigenicity of oral cancer cells via repression of SOX2 |pdf=|usr=}}{{24918581 }} gab.com Text QKI impairs self-renewal and tumorigenicity of oral cancer cells via repression of SOX2 JO: Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=24918581 #FOAvip Cancer stem cells (CSCs) may contribute to tumor initiation, distant metastasis and chemo-resistance. One of RNA-binding proteins, Quaking (QKI), was reported to be a tumor suppressor. Here we showed that reduced QKI levels were observed in many human oral cancer samples. Moreover further reduction of QKI expression in CSCs was detected compared with non-CSCs in oral cancer cell lines. Overexpressing QKI in oral cancer cells significantly reduced CSC sphere formation and stem cell-associated genes. In tumor implanting nude mice model, QKI significantly impeded tumor initiation rates, tumor sizes and lung metastasis rates. As a contrast, knocking down QKI enhanced the above effects. Among the putative CSC target genes, SOX2 expression was negatively affected by QKI, mechanism study revealed that QKI may directly regulate SOX2 expression via specific binding with its 3'UTR in a cis element-dependent way. Loss of SOX2 even completely reversed the sphere forming ability in QKI knockdown cell line. Taken together, these data demonstrated that SOX2 is an important CSC regulator in oral cancer. QKI is a novel CSC inhibitor and impaired multiple oral CSC properties via partial repression of SOX2. Therefore, reduced expression of QKI may provide a novel diagnostic marker for oral cancer. Twit Text FOAVip QKI impairs self-renewal and tumorigenicity of oral cancer cells via repression of SOX2 ????Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=24918581 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24918581 #FOAvip English Wikipedia <ref>{{Cite pmid|24918581 }}</ref> QKI impairs self-renewal and tumorigenicity of oral cancer cells via repression of SOX2 #MMPMID24918581 Lu W ; Feng F ; Xu J ; Lu X ; Wang S ; Wang L ; Lu H ; Wei M ; Yang G ; Wang L ; Lu Z ; Liu Y ; Lei X Cancer Biol Ther 2014[Sep]; 15 (9 ): 1174-84 PMID24918581 show ga Cancer stem cells (CSCs) may contribute to tumor initiation, distant metastasis and chemo-resistance. One of RNA-binding proteins, Quaking (QKI), was reported to be a tumor suppressor. Here we showed that reduced QKI levels were observed in many human oral cancer samples. Moreover further reduction of QKI expression in CSCs was detected compared with non-CSCs in oral cancer cell lines. Overexpressing QKI in oral cancer cells significantly reduced CSC sphere formation and stem cell-associated genes. In tumor implanting nude mice model, QKI significantly impeded tumor initiation rates, tumor sizes and lung metastasis rates. As a contrast, knocking down QKI enhanced the above effects. Among the putative CSC target genes, SOX2 expression was negatively affected by QKI, mechanism study revealed that QKI may directly regulate SOX2 expression via specific binding with its 3'UTR in a cis element-dependent way. Loss of SOX2 even completely reversed the sphere forming ability in QKI knockdown cell line. Taken together, these data demonstrated that SOX2 is an important CSC regulator in oral cancer. QKI is a novel CSC inhibitor and impaired multiple oral CSC properties via partial repression of SOX2. Therefore, reduced expression of QKI may provide a novel diagnostic marker for oral cancer. |3' Untranslated Regions [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |Gene Knockdown Techniques [MESH] |Humans [MESH] |Lung Neoplasms/metabolism/secondary [MESH] |Mice, Nude [MESH] |Mouth Neoplasms/metabolism/*pathology [MESH] |Neoplastic Stem Cells/metabolism/pathology [MESH] |RNA-Binding Proteins/genetics/*metabolism [MESH]QKI impairs self-renewal and tumorigenicity of oral cancer cells via r(epmc).pdf DeepDyve Pubget Overpricing