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10.1016/j.cellimm.2014.05.013 http://scihub22266oqcxt.onion/10.1016/j.cellimm.2014.05.013 C4128186!4128186!24978612     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Immunol 2014 ; 290 (1): 120-30 Nephropedia Template TP {{tp|p=24978612|t=2014. Glucocorticoids regulate natural killer cell function epigenetically |pdf=|usr=}}{{24978612}} gab.com Text Glucocorticoids regulate natural killer cell function epigenetically JO: Cell Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24978612 #FOAvip Although glucocorticoids are well known for their capacity to suppress the immune response, glucocorticoids can also promote immune responsiveness. It was the purpose of this investigation to evaluate the molecular basis for this apparent dichotomous immunologic effect. Glucocorticoid treatment of natural killer cells (NK) was shown to reduce NK cell cytolytic activity by reduction of histone promoter acetylation for perforin and granzyme B, which corresponded with reduced mRNA and protein for each. In contrast, glucocorticoid treatment increased histone acetylation at regulatory regions for interferon gamma and IL-6, as well as chromatin accessibility for each. This increase in histone acetylation was associated with increased proinflammatory cytokine mRNA and protein production upon cellular stimulation. These immunologic effects were evident at the level of the individual cell and demonstrate glucocorticoids to epigenetically reduce NK cell cytolytic activity while at the same time to prime NK cells for proinflammatory cytokine production. Twit Text FOAVip Glucocorticoids regulate natural killer cell function epigenetically ????Cell Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24978612 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24978612 #FOAvip English Wikipedia <ref>{{Cite pmid|24978612}}</ref> Glucocorticoids regulate natural killer cell function epigenetically #MMPMID24978612 Eddy JL; Krukowski K; Janusek L; Mathews HL Cell Immunol 2014[Jul]; 290 (1): 120-30 PMID24978612show ga Although glucocorticoids are well known for their capacity to suppress the immune response, glucocorticoids can also promote immune responsiveness. It was the purpose of this investigation to evaluate the molecular basis for this apparent dichotomous immunologic effect. Glucocorticoid treatment of natural killer cells (NK) was shown to reduce NK cell cytolytic activity by reduction of histone promoter acetylation for perforin and granzyme B, which corresponded with reduced mRNA and protein for each. In contrast, glucocorticoid treatment increased histone acetylation at regulatory regions for interferon gamma and IL-6, as well as chromatin accessibility for each. This increase in histone acetylation was associated with increased proinflammatory cytokine mRNA and protein production upon cellular stimulation. These immunologic effects were evident at the level of the individual cell and demonstrate glucocorticoids to epigenetically reduce NK cell cytolytic activity while at the same time to prime NK cells for proinflammatory cytokine production. äGlucocorticoids regulate natural killer cell function epigenetically (epmc).pdf DeepDyve Pubget Overpricing