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10.1038/ncomms5196 http://scihub22266oqcxt.onion/10.1038/ncomms5196 C4127490!4127490!24943270     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2014 ; 5 (ä): 4196 Nephropedia Template TP {{tp|p=24943270|t=2014. Disruption of astrocyte-vascular coupling and the blood-brain barrier by invading glioma cells |pdf=|usr=}}{{24943270}} gab.com Text Disruption of astrocyte-vascular coupling and the blood-brain barrier by invading glioma cells JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=24943270 #FOAvip Astrocytic endfeet cover the entire cerebral vasculature and serve as exchange sites for ions, metabolites, and energy substrates from the blood to the brain. They maintain endothelial tight junctions that form the blood-brain barrier (BBB) and release vasoactive molecules that regulate vascular tone. Malignant gliomas are highly invasive tumors that use the perivascular space for invasion and co-opt existing vessels as satellite tumors form. Here we use a clinically relevant mouse model of glioma and find that glioma cells, as they populate the perivascular space of pre-existing vessels, displace astrocytic endfeet from endothelial or vascular smooth muscle cells. This causes a focal breach in the BBB. Furthermore, astrocyte-mediated gliovascular coupling is lost, and glioma cells seize control over regulation of vascular tone through Ca2+-dependent release of K+. These findings have important clinical implications regarding blood flow in the tumor-associated brain and the ability to locally deliver chemotherapeutic drugs in disease. Twit Text FOAVip Disruption of astrocyte-vascular coupling and the blood-brain barrier by invading glioma cells ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=24943270 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24943270 #FOAvip English Wikipedia <ref>{{Cite pmid|24943270}}</ref> Disruption of astrocyte-vascular coupling and the blood-brain barrier by invading glioma cells #MMPMID24943270 Watkins S; Robel S; Kimbrough IF; Robert SM; Ellis-Davies G; Sontheimer H Nat Commun 2014[]; 5 (ä): 4196 PMID24943270show ga Astrocytic endfeet cover the entire cerebral vasculature and serve as exchange sites for ions, metabolites, and energy substrates from the blood to the brain. They maintain endothelial tight junctions that form the blood-brain barrier (BBB) and release vasoactive molecules that regulate vascular tone. Malignant gliomas are highly invasive tumors that use the perivascular space for invasion and co-opt existing vessels as satellite tumors form. Here we use a clinically relevant mouse model of glioma and find that glioma cells, as they populate the perivascular space of pre-existing vessels, displace astrocytic endfeet from endothelial or vascular smooth muscle cells. This causes a focal breach in the BBB. Furthermore, astrocyte-mediated gliovascular coupling is lost, and glioma cells seize control over regulation of vascular tone through Ca2+-dependent release of K+. These findings have important clinical implications regarding blood flow in the tumor-associated brain and the ability to locally deliver chemotherapeutic drugs in disease. äDisruption of astrocyte-vascular coupling and the blood-brain barrier (epmc).pdf DeepDyve Pubget Overpricing